Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

• DOI: 10.7554/elife.91392.3
• Publication Date: 2024-04-24T10:35:41Z
• Authors: Rajan M Thomas; Matthew C Pahl; Liqing Wang; Struan FA Grant; Wayne W Hancock; Andrew D Wells
• Keywords: Regulatory T cell; Epigenome

Ikaros is a transcriptional factor required for conventional T cell development, differentiation, and anergy. While the related factors Helios Eos have defined roles in regulatory cells (Treg), role has not been established. To determine function of Treg lineage, we generated mice with Treg-specific deletion gene ( Ikzf1 ). We find that cooperates Foxp3 to establish major portion epigenome transcriptome. Ikaros-deficient exhibit Th1-like expression abnormal production IL-2, IFNg, TNFa, involved Wnt Notch signaling. -Treg-cko do develop spontaneous autoimmunity, are unable control cell-mediated immune pathology response TCR inflammatory stimuli models IBD organ transplantation. These studies as core tolerance responses.