Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

• DOI: 10.7554/elife.92095
• Publication Date: 2023-12-20T20:01:15Z
• Authors: John J Maurer; Alexandra Lin; Xi Jin; Jiso Hong; Nicholas Sathi; Romain Cardis; Alejandro Osorio-...; Anita Lüthi; Franz Weber; Shinjae Chung
• Keywords: Preoptic area; Sleep; Homeostasis

Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation mice. POA most active during REMs, inhibiting them specifically decreases REMs. restriction leads an increased number amplitude calcium transients neurons, reflecting accumulation pressure. Inhibiting blocked rebound Our findings reveal hypothalamic circuit whose activity mirrors buildup pressure required ensuing