Senescence of endplate osteoclasts induces sensory innervation and spinal pain

• DOI: 10.7554/elife.92889.3
• Publication Date: 2024-06-19T15:08:14Z
• Authors: Dayu Pan; Kheiria Gamal Ben...; Xuequan Han; Jinjian Zheng; Vijay Kumar; Mei Wan; Junying Zheng; Xu Cao
• Keywords: Degeneration (medical); Senescence

Spinal pain affects individuals of all ages and is the most common musculoskeletal problem globally. Its clinical management remains a challenge as underlying mechanisms leading to it are still unclear. Here, we report that significantly increased numbers senescent osteoclasts (SnOCs) observed in mouse models spinal hypersensitivity, like lumbar spine instability (LSI) or aging, compared controls. The larger population SnOCs associated with induced sensory nerve innervation, well growth H-type vessels, porous endplate. We show deletion cells by administration senolytic drug Navitoclax (ABT263) results less degeneration, porosity endplate, vessel also there SnOC-mediated secretion Netrin-1 NGF, two well-established factors, non-senescent OCs. These findings suggest pharmacological elimination may be potent therapy treat pain.