The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

• DOI: 10.7554/elife.93124
• Publication Date: 2024-01-24T13:25:12Z
• Authors: Alejandro Alonso-...; Alessia Perino; Frédérica Schyrr; Silvia Ferreira L...; Vasiliki Delitsikou; Antoine Jalil; Ulrike Kettenberger; Dominique P. Piol...; Kristina Schoonjans; Olaia Naveiras
• Keywords: 0301 basic medicine; 03 medical and health sciences

The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we investigated young mice observed significant reduction adipose tissue (BMAT) upon loss TGR5, accompanied by enrichment adipocyte progenitors which translated into enhanced hematopoietic recovery transplantation. These findings open possibility modulating stromal support acting signaling.This work shows loss-of-function reduces regulated accelerates data highlight key player microenvironment.