Novel risk loci for COVID-19 hospitalization among admixed American populations
Male
QH301-705.5
none
Science
SNP
American populations
Novel risk loci
Polymorphism, Single Nucleotide
Risk Factors
None
genomics
Genetics
GWAS
Humans
genetics
Genetic Predisposition to Disease
Biology (General)
Aged
Medicina. Salud
SARS-CoV-2
Q
R
COVID-19
Genetics and Genomics
Genomics
Middle Aged
Hospitalization
Latin America
Genetic Loci
Medicine
Female
Genome-Wide Association Study
DOI:
10.7554/elife.93666.1
Publication Date:
2024-02-14T15:26:04Z
AUTHORS (122)
ABSTRACT
Abstract
The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (58)
CITATIONS (0)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....