Novel risk loci for COVID-19 hospitalization among admixed American populations

2019-20 coronavirus outbreak
DOI: 10.7554/elife.93666.1 Publication Date: 2024-02-14T15:26:04Z
AUTHORS (122)
ABSTRACT
The genetic basis of severe COVID-19 has been thoroughly studied and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted largest GWAS meta-analysis for hospitalization admixed Americans, comprising a total 4,702 hospitalized cases recruited by other seven participating studies Host Genetic Initiative. We identified four genome-wide significant associations, two which constitute novel loci first discovered Latin-American ( BAZ2B DDIAS ). A trans-ethnic revealed another cross-population locus CREBBP . Finally, assessed performance cross-ancestry polygenic score American cohort.
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