Novel risk loci for COVID-19 hospitalization among admixed American populations

• DOI: 10.7554/elife.93666.1
• Publication Date: 2024-02-14T15:26:04Z
• Authors: Silvia Diz-de Alm...; Raquel Cruz; Andre D. Luchessi; José M. Lorenzo-S...; Miguel López de H...; Inés Quintela; Rafaela González-...; Vivian N. Silbiger; Marta Sevilla Porras; Jair Antonio Teno...; Julian Nevado; Jose María Aguado; Carlos Aguilar; Sergio Aguilera-A...; Virginia Almadana; Berta Almoguera; Nuria Alvarez; Álvaro Andreu-Ber...; Eunate Arana-Arri; Celso Arango; María J. Arranz; Maria-Jesus Artiga; Raúl C. Baptista-...; María Barreda- Sá...; Moncef Belhassen-...; Joao F. Bezerra; Marcos A.C. Bezerra; Lucía Boix-Palop; María Brion; Ramón Brugada; Matilde Bustos; Enrique J. Calderón; Cristina Carbonell; Luis Castano; Jose E. Castelao; Rosa Conde- Vicente; M. Lourdes Corder...; Jose L. Cortes-Sa...; Marta Corton; M. Teresa Darnaude; Alba De Martino-R...; Victor del Campo-...; Aranzazu Diaz de ...; Elena Domínguez-G...; Rocío Eirós; María Carmen Fariñas; María J. Fernande...; Uxía Fernández-Ro...; Amanda Fernández-...; Tania Fernández-V...; Manuela Gago-Domí...; Belén Gil-Fournier; Javier Gómez- Arrue; Beatriz González ...; Fernan Gonzalez B...; Anna González-Neira; Javier González-P...; Juan F. Gutiérrez...; María José Herrero; Antonio Herrero-G...; María A. Jimenez-...; María Claudia Lattig; Anabel Liger Borja; Rosario Lopez-Rod...; Esther Mancebo; Caridad Martín- L...; Vicente Martín; Oscar Martinez-Nieto; Iciar Martinez-Lopez; Michel F. Martine...; Ángel Martinez-Perez; Juliana F. Mazzeu; Eleuterio Merayo ...; Pablo Minguez; Victor Moreno Cuerda; Silviene F. Oliveira; Eva Ortega-Paino; Mara Parellada; Estela Paz-Artal; Ney P.C. Santos; Patricia Pérez- M...; Patricia Perez; M. Elena Pérez-Tomás; Teresa Perucho; Mel·lina Pinsach-...; Guillermo Pita; Ericka N. Pompa-Mera; Gloria L. Porras-...; Aurora Pujol; Soraya Ramiro León; Salvador Resino; Marianne R. Ferna...; Emilio Rodríguez-...; Fernando Rodrigue...; José A. Rodriguez...; Francisco Ruiz-Ca...; Javier Ruiz-Horni...; Pablo Ryan; José Manuel Soria; Juan Carlos Souto; Eduardo Tamayo; Alvaro Tamayo-Vel...; Juan Carlos Tarac...; Alejandro Teper; Lilian Torres-Tobar; Miguel Urioste; Juan Valencia-Ramos; Zuleima Yáñez; Ruth Zarate; Itziar de Rojas; Agustín Ruiz; Pascual Sánchez; Luis Miguel Real; ; Encarna Guillen-N...; Carmen Ayuso; Esteban Parra; José A. Riancho; Augusto Rojas-Mar...; Carlos Flores; Pablo Lapunzina; Ángel Carracedo
• Keywords: Male; QH301-705.5; none; Science; SNP; American populations; Novel risk loci; Polymorphism, Single Nucleotide; Risk Factors; None; genomics; Genetics; GWAS; Humans; genetics; Genetic Predisposition to Disease; Biology (General); Aged; Medicina. Salud; SARS-CoV-2; Q; R; COVID-19; Genetics and Genomics; Genomics; Middle Aged; Hospitalization; Latin America; Genetic Loci; Medicine; Female; Genome-Wide Association Study

Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.