Novel risk loci for COVID-19 hospitalization among admixed American populations

Male QH301-705.5 none Science SNP American populations Novel risk loci Polymorphism, Single Nucleotide Risk Factors None genomics Genetics GWAS Humans genetics Genetic Predisposition to Disease Biology (General) Aged Medicina. Salud SARS-CoV-2 Q R COVID-19 Genetics and Genomics Genomics Middle Aged Hospitalization Latin America Genetic Loci Medicine Female Genome-Wide Association Study
DOI: 10.7554/elife.93666.1 Publication Date: 2024-02-14T15:26:04Z
AUTHORS (122)
ABSTRACT
Abstract The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the largest GWAS meta-analysis for COVID-19 hospitalization in admixed Americans, comprising a total of 4,702 hospitalized cases recruited by SCOURGE and other seven participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and first discovered in Latin-American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort.
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