Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

• DOI: 10.7554/elife.94349
• Publication Date: 2024-02-07T13:20:44Z
• Authors: Moneeza A Agha; Sandeep Kishore; David L McLean
• Keywords: Reciprocal inhibition; Nerve net

Different speeds of locomotion require heterogeneous spinal populations, but a common mode rhythm generation is presumed to exist. Here, we explore the cellular versus synaptic origins rhythmicity at different by performing electrophysiological recordings from premotor excitatory interneurons in larval zebrafish. Chx10-labeled V2a neurons are divided into least two morphological subtypes proposed play distinct roles timing and intensity control. Consistent with generating output patterning functions within population, find that descending recruited exclusively slow or fast exhibit intrinsic properties suitable for rhythmogenesis those speeds, while bifurcating more reliably all lack appropriate rhythmogenic properties. Unexpectedly, however, phasic firing patterns during non-rhythmogenic alike best explained modes inhibition linked cell type speed. At reciprocal supports firing, recurrent helps pattern motor output. In contrast, rely on alone Our findings suggest cell-type-specific, not common, generate coordinate locomotion.