The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

• DOI: 10.7554/elife.95292.2
• Publication Date: 2024-12-04T15:25:19Z
• Authors: Benita Martin-Cas...; Patricia Diez-Echave; Jorge García-García; Laura Hidalgo-García; Antonio Jesús Rui...; José Alberto Moli...; Maria Jesús Rodrí...; Anaïs Redruello; Margarita Martíne...; Emilio Mota; Fernando Cobo; Marta Alvarez-Est...; Federico García; Concepción Morale...; Silvia Merlos; Paula García-Flores; Manuel Colmenero-...; José Hernandez-Quero; María Nuñez; Maria Elena Rodrí...; Ángel Carazo; Javier Martín; Rocío Morón; Alba Rodríguez-No...; Julio Gálvez
• Keywords: Dysbiosis; Coronavirus

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play key role the infection, progression, outcome of disease. SARS-CoV-2 infection has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens. To identify new prognostic markers for disease, multicenter prospective observational cohort study was carried out COVID-19 patients divided into three cohorts based on symptomatology: mild (n=24), moderate (n=51), severe/critical (n=31). Faecal samples were taken, analyzed. Linear discriminant analysis identified M. salivarium , P. dentalis H. parainfluenzae as biomarkers microbiota, while bivia timonensis defined faecal microbiota. Additionally, connection between identified, significant ratio (faeces) (nasopharyngeal) abundances found critically ill patients. This serve novel tool identifying cases.