Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review

• DOI: 10.7555/jbr.36.20220088
• Publication Date: 2022-06-18T02:33:15Z
• Authors: Gaochen Lu; Quan Wen; Bota Cui; Qianqian Li; Faming Zhang
• Keywords: Fecal bacteriotherapy

Amyotrophic lateral sclerosis (ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, has an average survival time three to five years. Growing evidence suggested bidirectional link between gut microbiota neurodegeneration. Here we aimed report one female case with ALS, who benefited from washed transplantation (WMT), improved fecal (FMT), through transendoscopic enteral tube during 12-month follow-up. Notedly, the accidental scalp trauma patient suffered later was treated prescribed antibiotics that caused ALS deterioration. The subsequent rescue WMTs successfully stopped progression disease quick improvement. plateaus reversals occurred whole course WMT. stool blood samples first WMT last were collected for dynamic microbial metabolomic analysis. We observed changing trend consistent status. This shows direct clinical on using treating indicating may be novel treatment strategy controlling this so-called incurable disease.