Numerical investigation of perforated polymer microcantilever sensor for contractile behavior of cardiomyocytes

• DOI: 10.7567/jjap.56.06gm01
• Publication Date: 2017-05-15T09:14:06Z
• Authors: Trieu Khoa Nguyen; Dong-Weon Lee; Bong-Kee Lee
• Keywords: 02 engineering and technology; 0210 nano-technology

In this study, a numerical investigation of microcantilever sensors for detecting the contractile behavior cardiomyocytes (CMs) was performed. Recently, novel surface-patterned perforated SU-8 sensor has been developed preliminary screening cardiac toxicity. From motion CMs cultured on surface, macroscopic bending obtained, which is considered to reflect physiological change. As continuation previous research, method based surface traction model proposed and verified further understand microcantilevers. Effects various factors, including magnitude, focal area CMs, stiffness microcantilever, displacement were investigated. static transient analyses, found be most crucial factor. addition, current result can provide design guideline micromechanical devices same principle.