The coalescent with replication-independent mutations

• DOI: 10.7717/peerj.12926
• Publication Date: 2022-02-15T09:27:26Z
• Authors: Stephen M. Krone; Beth M. Tuschhoff
• Keywords: Coalescent theory; Replication; Genetic drift

We develop the mathematical structure of neutral coalescent with both replication-dependent and replication-independent mutations. This allows us to explain quantify empirical results that explore differences in genetic diversity bacterial cultures different growth rates. also derive an unbiased consistent estimator for mutation rate is based on a comparison total single nucleotide polymorphism counts two independent well-mixed In addition explaining between (but constant) rates, our quantifies effects fluctuating rates-a situation can be common natural populations.