Temporal and spatial differences in the vaginal microbiome of Chinese healthy women

• DOI: 10.7717/peerj.16438
• Publication Date: 2023-12-02T07:15:36Z
• Authors: Limin Du; Xue Dong; Jiarong Song; Tingting Lei; Xianming Liu; Yue Lan; Xu Liu; Jiao Wang; Bisong Yue; Miao He; Zhenxin Fan; Tao Guo
• Keywords: QH301-705.5; Bioinformatics; Microbiota; R; East Asian People; Cervix Uteri; Healthy women; Lactobacillus; Vagina; Medicine; Humans; Female; Vagina microbiome; Biology (General); Menstrual cycle; Metagenomic sequencing

Background Up the reproductive tract, there are large differences in composition of vaginal microbes. Throughout menstrual cycle, structure microbiome shifts. Few studies have examined both combination. Our study was designed to explore trends different parts vagina healthy women over cycle. Methods We performed metagenomic sequencing characterize between cervical orifice and mid-vagina throughout Results results showed similar during periovulatory luteal phases, with Lactobacillus being dominant bacteria. In follicular phase, Acinetobacter detected orifice. From phase community state types (all five status were defined as CSTs) samples No. 10 11 changed from CST III I. addition, regions China significantly different. also viruses including Human alphaherpesvirus 1 (HSV-1) phase. Conclusion This is valuable for understanding whether microbial consistent