Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer—A retrospective study

• DOI: 10.7717/peerj.18717
• Publication Date: 2025-01-02T08:18:11Z
• Authors: Ruifang Zeng; Hanyu Wang; Xiaojun Cai; Junhao Lin; Pengfei Li; Shan Zeng; Aimin Li
• Keywords: Breast cancer; Survival; Recurrence; QH301-705.5; R; Medicine; Computational Biology; Biology (General); Side effects; Low-dose radiation

Purpose The purpose of this study was to determine the efficacy and safety low-dose radiotherapy (LDR) for postoperative local chest wall recurrence breast cancer. Methods records 52 patients with recurrent cancer treated at our center from January 2019 December 2022. t-test used compare means LDR group non group. Categorical data were compared using chi-square test. Kaplan-Meier method factors associated survival. Results Compared who did not undergo LDR, in showed a higher incidence grade I side effects their skin soft tissue systems ( p = 0.002), significant reduction II < 0.05), no III effects. group, complete response rates 42.3% vs . 38.5%, 0.777, partial 53.8% 50.0%, 0.781, objective relief 96.2% 88.5%, 0.833, respectively. 3-year overall survival rate, free distant metastasis-free rate disease-specific comparison between 54.8% 55.8%, 0.845 54.2% 52.9%, 0.751, 67.9% 51.9%, 0.097 39.2% 49.6%, 0.993, Conclusion traditional radiotherapy, pre-irradiation has better tolerance after operation.