Is there any effect of pneumoperitoneum pressure on coagulation and fibrinolysis during laparoscopic cholecystectomy?

• DOI: 10.7717/peerj.2375
• Publication Date: 2016-09-08T08:07:06Z
• Authors: Turgut Donmez; Sinan Uzman; Dogan Yildirim; Adnan Hut; Huseyin Imam Avar...; Duygu Ayfer Erdem; Erdinc Cekic; Fazilet Erozgen
• Keywords: Prothrombin time; Thrombin time

Background Laparoscopic cholecystectomies (LC) are generally performed in a 12 mmHg-pressured pneumoperitoneum slight sitting position. Considerable thromboembolism risk arises this operation due to pneumoperitoneum, position and factors of patients. We aim investigate the effect pressure on coagulation fibrinolysis under general anesthesia. Material Methods Fifty American Society Anesthesiologist (ASA) I–III patients who underwent elective LC without thromboprophlaxis were enrolled prospective study. The randomly divided into two groups according during LC: 10 mmHg group ( n = 25) 14 group. Prothrombin time (PT), thrombin (TT), International Normalized Ratio (INR), activated partial thromboplastin (aPTT) blood levels d-dimer fibrinogen measured preoperatively (pre), one hour (post1) 24 h (post24) after surgery. Moreover, alanine amino transferase, aspartate transferase lactate dehydrogenase before These parameters compared between within groups. Results PT, TT, aPTT, INR, D-dimer significantly increased surgery both level was higher 14-mmHg at post24. Conclusion Both 10-mmHg may lead affect tests any occurrence deep vein thrombosis, but has greater D-dimer. However, lower be useful for prevention thrombosis.