Clinicopathological characteristics, treatment and survival of pulmonary large cell neuroendocrine carcinoma: a SEER population-based study

• DOI: 10.7717/peerj.6539
• Publication Date: 2019-03-27T16:45:16Z
• Authors: Ling Cao; Zhi-wen Li; Min Wang; Ting-ting Zhang; Bo Bao; Yun-peng Liu
• Keywords: Univariate analysis

Background This study was designed to investigate the clinicopathological characteristics, treatment and survival of patients with pulmonary large cell neuroendocrine carcinoma (LCNEC). Methods The Surveillance, Epidemiology End Results database utilized identify diagnosed LCNEC between 2004 2013. Kaplan–Meier analysis conducted determine overall (OS) cancer-specific (CSS) rate. Univariate along log-rank test, Cox proportional hazards model were employed detect independent prognostic factors. Pulmonary accounted for 0.58% (2972/510607) total number lung bronchus carcinoma. And a 1,530 eligible cases identified, median follow-up time 11 months. To be specific, 3-, 5-year OS CSS rates 22.8%, 16.8% 26.5%, 20.8% respectively. Generally, commonly detected in elderly (72.2%), males (55.9%), upper lobe (62.0%) advanced AJCC stage (65.5%). Multivariate revealed that [(≥60 <80 years) HR:1.203, 95% CI [1.053–1.375], P = 0.007; (≥80 HR:1.530, [1.238–1.891], < 0.001] [(stage III) HR:2.606, [2.083–3.260], 0.001; (stage IV) HR:4.881, [3.923–6.072], unfavorable factors, female (HR:0.845, [0.754–0.947], 0.004)), surgery [(Segmentectomy/wedge resection) HR:0.526, [0.413–0.669], (Lobectomy/Bilobectomy) HR:0.357, [0.290–0.440], 0.001;(Pneumonectomy) HR:0.491, [0.355–0.679], , chemotherapy (HR:0.442, [0.389–0.503], 0.001) radiation (HR:0.837, [0.738–0.949], 0.005) favorable Conclusion sum up, age at diagnosis, sex, 8th edition stage, surgery, significantly associated LCNEC.