Prognostic value of CLIC3 mRNA overexpression in bladder cancer

• DOI: 10.7717/peerj.8348
• Publication Date: 2020-01-06T09:05:08Z
• Authors: Mei Chen; Shufang Zhang; Xiaohong Wen; Hui Cao; Yuanhui Gao
• Keywords: KEGG

Human intracellular chloride channel 3 (CLIC3) is involved in the development of various cancers, but expression and prognostic value CLIC3 mRNA bladder cancer (BC) remain unclear.The gene data clinical information were obtained from Gene Expression Omnibus (GEO) database verified Oncomine The Cancer Genome Atlas (TCGA) database. BC tissues adjacent normal was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Kaplan-Meier method used to analyze relationship between prognosis BC. Cox univariate multivariate analyses performed on overall survival tumor-specific patients. genes coexpressed with analyzed Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). CLIC3-related signal transduction pathways explored set enrichment analysis (GSEA).The higher than that (P < 0.01). High associated age = 0.021) grade 0.045) predicted a poor patients 0.05). showed high Functional indicated may be significantly cell cycle, focal adhesion, extracellular matrix (ECM) receptor interaction P53 signaling pathway.CLIC3 highly expressed BC, its related adverse clinicopathological factors can as biomarker for