Resection vs. ablation for lesions characterized as resectable-ablative within the colorectal liver oligometastases criteria: a propensity score matching from retrospective study

• DOI: 10.7717/peerj.8398
• Publication Date: 2020-01-27T10:04:48Z
• Authors: Ma Luo; Si-Liang Chen; Jiawen Chen; Huzheng Yan; Zhenkang Qiu; Guanyu Chen; Ligong Lu; Fujun Zhang
• Keywords: Ablative case; Log-rank test; Univariate analysis

There has been no prospective or retrospective studies reporting the comparison outcome between surgery and ablation for resectable-ablative (lesions could be treated by resection complete ablation) colorectal liver oligometastases (CLOM). The purpose of this study was to compare efficacy prognostic difference in patients who underwent R0 vs. within CLOM criteria.From January 2008 May 2018, a total 2,367 diagnosed with metastases were included observational study. metastasis characterized only limited number ≤5, size ≤5 cm, ablation). evaluated indications, including progression-free survival (LPFS), overall (OS), rates, pattern recurrences, complications, compared using propensity score matching (PSM). Kaplan-Meier curves generated, log-rank test performed. Cox regression model used univariate multivariate analyses identify predictors outcomes.A 421 consecutive eligible study, 250 171 undergoing ablation, respectively. PSM identified 145 from each group. 1-, 3-, 5- 8-year OS rates group 95.8% 95.0%, 69.8% 60.1%, 53.6% 42.5%, 45.1% 32.9% (p = 0.075), median LPFS significantly longer than that (35 months 15 months, p 0.011). No statistical found two groups when comparing ≤3 cm metastases. For >3 11 5 respectively 0.001). In terms high risk clinical (CRS), showed (median 18 10 0.043).For criteria suggesting resectable as well ablative, result recurrence-free cases CRS. But metastases, their treatment efficacies comparable.