Using Blood and Plasma MicroRNAs as a Non-Invasive Biomarker in Patients with Colorectal Cancer

• DOI: 10.7754/clin.lab.2017.170819
• Publication Date: 2018-05-08T12:13:21Z
• Authors: Horatiu Stefanescu; Delia Muntean; Ciprian Pilut; Mircea Diaconu; Roxana Popescu; Delia Hutanu; Marius Moise; Lighezan Diana; Razvan Nitu; Alina Cherecheanu; Silvius Negoita; Ciprian Iovan; Emil Ungureanu; Valentin Calu; Ioana Ciuca
• Keywords: Gene Expression Regulation, Neoplastic; 0301 basic medicine; MicroRNAs; Review Literature as Topic; 03 medical and health sciences; Biomarkers, Tumor; Humans; Colorectal Neoplasms; Sensitivity and Specificity; Early Detection of Cancer; 3. Good health

A high percentage of oncological patients die yearly because colorectal cancer (CRC). Worldwide, CRC represents the fourth leading cause death among patients. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis with CRC. From this point view, an ideal biomarker is represented by expression microRNAs. In paper, we wish summarize expressions microRNAs and present pathophysiological genetic interactions that protein systems these patients.For looked into available scientific databases such as PubMed. For search following keywords used: "miRNAs expression", "colorectal cancer", "genetic polymorphisms CRC", CRC".Modifying can be used successfully both diagnosing their response chemotherapy. shown specificity certain microRNA species case An extraordinary advantage non-invasive sampling from urine blood. Moreover, a series connections some mechanisms involved appearance development shown. Therefore, named future, well epigenetic targeted treatment CRC.The evaluation monitoring However, further are needed regarding pathological specific