A Proposed Kinetic Model for the Diagnostic and Prognostic Value of WT1 and p53 in Acute Myeloid Leukemia

• DOI: 10.7754/clin.lab.2017.170915
• Publication Date: 2018-05-08T08:13:21Z
• Authors: Mohammad Bani-Ahmad; Suleimman Al-Sweedan; Mohammad Al-Asseiri; Ahed Alkhatib
• Keywords: Pathogenesis; P53 expression

Wilms tumor (WT1) and p53 proteins were identified in the pathogenesis of several malignancies, including hematological malignancies. As a result their interaction diverse context-specific functions, this study aimed to emphasize diagnostic prognostic impacts WT1 expression acute myeloid leukemia (AML).Twelve bone marrow (BM) biopsies obtained from AML patients who diagnosed accordance with French-American-British criteria. For comparative purposes, nine normal BM included. The rate determined by an immunohistochemistry assay.A significantly higher (p < 0.005) strongly correlated ( = 0.855, p 0.001) rates observed comparison control BM. Furthermore, relapsed had WT1, but not p53, when compared newly patients. In regard patient's responsiveness chemotherapy, no significant difference was reported between good poor responders. However, relative ratio evidently groups 0.05), where be among Poor responders characterized statistically dominant (p53/WT1 > 1.0) while both responding subjects 1.0).The enhanced levels is supportive intermediate role disease. may encompass negative value p53/WT serve as hallmark reveal chemotherapy. Herein, we are proposing kinetic model p53/WT1 might useful laboratory approach evaluate chemotherapeutic regimen.