Cervical Priming Before Diagnostic Operative Hysteroscopy in Infertile Women: A Randomized, Double-Blind, Controlled Comparison of 2 Vaginal Misoprostol Doses

• DOI: 10.9738/intsurg-d-12-00024.1
• Publication Date: 2013-05-23T14:58:28Z
• Authors: Ercan Bastu; Cem Celik; Asli Nehir; Murat Dogan; Bahar Yuksel; Bulent Ergun
• Keywords: Adult; Dose-Response Relationship, Drug; Cervix Uteri; Hysteroscopy; Dilatation; Drug Administration Schedule; 3. Good health; Cervical priming; Administration, Intravaginal; 03 medical and health sciences; 0302 clinical medicine; Office hysteroscopy; Double-Blind Method; Oxytocics; Premenopausal Women; Controlled-Trial; Outcome Assessment, Health Care; Preoperative Care; Humans; Female; Infertility, Female; Placebo; Misoprostol

The aim of this study was to evaluate the efficacy vaginal misoprostol for cervical priming at doses 200 mcg and 400 mcg, 12 15 hours before diagnostic office hysteroscopy (OH) without anesthesia in patients with infertility. Sixty infertile requiring a investigation infertility were included study. randomly allocated into 3 vaginally administered groups: (1) control group, (2) 200-mcg dose (3) 400-mcg group. Misoprostol significantly facilitated procedure OH: entry easier; procedural time shorter; baseline width larger; pain scoring lower groups compared Increasing from did not improve effect on dilation. is promising analog use OH. Since OH both have proven be effective regimens, may preferred. However, routine clinical usage, further research needed through large, randomized, controlled trials powered detect difference complications determine whether reduces