A5075817831- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Virology and Viral Diseases
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
Universidade Federal de Minas Gerais
2019-2025
Background From the end of 2016 until beginning 2019, Brazil faced a massive sylvatic yellow fever (YF) outbreak. The 2016–2019 YF epidemics affected densely populated areas, especially Southeast region, causing thousands deaths humans and non-human primates (NHP). Methodology/Principal findings We conducted molecular investigation virus (YFV) RNA in 781 NHP carcasses collected urban, urban-rural interface, rural areas Minas Gerais state, from January 2017 to December 2018. Samples were...
Beginning December 2016, sylvatic yellow fever (YF) outbreaks spread into southeastern Brazil, and Minas Gerais state experienced two YF waves (2017 2018). Following these massive waves, we screened 187 free-living non-human primate (NHPs) carcasses collected throughout the between January 2019 June 2021 for virus (YFV) using RTqPCR. One sample belonging to a Callithrix, in 2020, was positive YFV. The viral strain belonged same lineage associated with 2017-2018 outbreaks, showing continued...
Abstract We enrolled 21 patients with laboratory-confirmed yellow fever (YF), hospitalized at Eduardo de Menezes Hospital, Brazil, to be treated sofosbuvir, a drug approved for hepatitis C. Given the absence of specific YF antiviral treatments, off-label nonrandomized sofosbuvir treatment aimed address high disease severity and risk fatal outcomes. Patients received daily dose 400 mg from 4 10 days post–symptom onset. viral load (VL) comparisons were made between nontreated who either...
Yellow fever (YF) is an acute infectious disease caused by the yellow virus which transmitted mosquitoes. Neotropical primates are susceptible to infection, often presented as epizootic outbreaks. The aim was evaluate and characterize immune response against YF in different species of neotropical from Belo Horizonte Zoo. Vaccine 17DD administered 24 primates, with a single subcutaneous dose. Clinical exams, RNAemia, detection IgG neutralizing antibodies YFV were performed. In addition,...
Yellow fever virus (YFV) is the agent of yellow (YF), which affects both humans and non-human primates (NHP). Neotropical NHP are highly susceptible to YFV considered sentinels for circulation. Brazil faced a significant YF outbreak in 2017-2018, with over 2000 human cases epizootics cases, mainly State Minas Gerais, Brazil. This study aimed investigate whether circulation persisted after had subsided. To this end, carcass samples collected Gerais from 2021 2023 were screened YFV. RNA was...
The yellow fever (YF) vaccine consists of an attenuated virus, and despite its relative safety, some adverse events following YF vaccination have been described. At the end 2016, Brazil experienced most massive sylvatic outbreak over last 70 years intense campaign occurred in Minas Gerais state Southeast from 2016 to 2018. present study aimed develop a genotyping tool investigate 21 cases suspected vaccination. Initial silico analyses were performed using partial NS5 nucleotide sequences...
Yellow fever virus (YFV) is the causative agent of yellow (YF), a hemorrhagic and viscerotropic acute disease. Severe YF has been described in approximately 15-25% patients, with 20-50% severe cases being fatal. Here we analyzed cerebrospinal fluid (CSF) samples collected during outbreak Brazil 2018, aiming to investigate CNS neuroinvasion fatal YFV cases. RNA was screened by RT-qPCR targeting 3’UTR region genome CSF. CSF were tested for presence anti-YFV IgM neutralizing antibodies, coupled...
Yellow fever virus (YFV) circulates in a sylvatic cycle between non-human primates (NHPs) and arboreal mosquitoes Brazil. Passive monitoring of ill or deceased NHPs is key component the Brazilian yellow (YF) surveillance program. Samples from carcasses are usually suitable for molecular tests but not serological assays. As an alternative to conventional plaque reduction neutralization test (PRNT) based on sera, we tested utility liver homogenates experimentally infected (YFV, Mayaro [MAYV],...
ABSTRACT Yellow fever virus (YFV) circulates in a sylvatic cycle between non-human primates (NHPs) and arboreal mosquitoes Brazil. Passive monitoring of ill or deceased NHPs is key component the Brazilian yellow (YF) surveillance program. Samples from carcasses are usually suitable for molecular tests but not serological assays. As an alternative to conventional plaque reduction neutralization test (PRNT) based on sera, we tested utility liver homogenates experimentally infected (YFV, Mayaro...
Abstract Beginning December 2016, sylvatic yellow fever (YF) outbreaks spread into southeastern Brazil, and Minas Gerais state experienced two YF waves (2017 2018). Following these massive waves, we screened 187 free-living non-human primate (NHPs) carcasses collected throughout the between January 2019 June 2021 for virus (YFV) using qPCR. One sample belonging to a Callithrix , in 2020, was positive YFV. The viral strain belonged same lineage associated with 2017-2018 outbreaks, showing...