A5078534593- RNA Research and Splicing
- Electron Spin Resonance Studies
- Photosynthetic Processes and Mechanisms
- Hemoglobin structure and function
- RNA modifications and cancer
- Nuclear Structure and Function
- Viral Infections and Immunology Research
- RNA regulation and disease
- Blood groups and transfusion
- Systemic Lupus Erythematosus Research
- Microbial metabolism and enzyme function
- RNA and protein synthesis mechanisms
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Glycation End Products research
- interferon and immune responses
- Traditional Chinese Medicine Analysis
- Animal Virus Infections Studies
- Gout, Hyperuricemia, Uric Acid
- SARS-CoV-2 and COVID-19 Research
- Erythrocyte Function and Pathophysiology
Vanderbilt University
2020-2025
Hangzhou Medical College
2022-2023
Zhejiang Provincial People's Hospital
2019-2023
Significance To successfully establish infection, viral pathogens have to overcome the interferon (IFN)-mediated antiviral response. Previous studies revealed that accessory protein Orf6 of SARS-CoV and SARS-CoV-2 is able inhibit STAT1 nuclear translocation block IFN signaling. In this study, we report localizes at pore complex (NPC) where it binds directly Nup98-Rae1 target import pathway mediate inhibition. A better understanding strategies used by viruses subvert host immune responses...
The nonstructural protein 1 (Nsp1) of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is a virulence factor that targets multiple cellular pathways to inhibit host gene expression and antiviral response. However, the underlying mechanisms various Nsp1-mediated functions their contributions remain unclear. Among Nsp1 mRNA (messenger ribonucleic acid) export receptor NXF1-NXT1, which mediates nuclear mRNAs from nucleus cytoplasm. Based on crystal structure, we generated mutants...
mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein particles (mRNPs) the nucleus and exported to cytoplasm for translation. mRNP packaging export require evolutionarily conserved transcription-export (TREX) complex. TREX facilitates loading of various RNA-binding proteins on through action its DDX39B subunit. SARNP (Tho1 [transcriptional defect Hpr1 by overexpression 1] yeast) shown interact with affect export. The molecular mechanism how recognizes functions...
Elevated serum uric acid (sUA) is associated with increasing risk of coronary heart disease (CHD). However, existing research limited by potential confounders. Herein, our study aims to probe the association between sUA levels and morphological characteristics plaque a propensity score matching (PSM) analysis.All 420 patients CHD who had undergone optical coherence tomography culprit lesions were included. Eligible assigned into 2 groups according level: high-sUA group (sUA ≥ 6.0 mg/dL)...
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5′ end with a 7-methylguanosine (m 7 G) cap, which is recognized nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism, including transcription, splicing, polyadenylation, and export. It promotes export through direct interaction key factor, ALYREF, turn links TRanscription EXport (TREX) to of mRNA. However, molecular mechanism for CBC-mediated recruitment machinery not well understood....
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5' end with a 7-methylguanosine (m7G) cap, which is recognized nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism, including transcription, splicing, polyadenylation, and export. It promotes export through direct interaction key factor, ALYREF, turn links TRanscription EXport (TREX) to of mRNA. However, molecular mechanism for CBC-mediated recruitment machinery not well understood....
The aim of our work was to test whether thymosin beta 4 protected endothelial progenitor cells against apoptosis induced by advanced glycation endproducts and investigate the underlying mechanism. Treatment with or transfection microRNA-34a inhibitor enhanced cell viability, reduced apoptosis, abated oxidative stress, attenuated mitochondrial dysfunction in exposed endproducts. Incubation led increased levels microRNA-34a, which treatment 4. Transfection reversed beneficial effect injuries...
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5’ end with a 7-methylguanosine (m 7 G) cap, which is recognized nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism including transcription, splicing, polyadenylation and export. It promotes export through direct interaction ALYREF, turn links TRanscription EXport (TREX) to of mRNA. However, molecular mechanism for mediated recruitment machinery not well understood. Here, we present...
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5’ end with a 7-methylguanosine (m 7 G) cap, which is recognized nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism including transcription, splicing, polyadenylation, and export. It promotes export through direct interaction key factor, ALYREF, turn links TRanscription EXport (TREX) to of mRNA. However, molecular mechanism for mediated recruitment machinery not well understood. Here,...
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5' end with a 7-methylguanosine (m