One of the causes hypertension is excess weight gain, which can also affect course this disease. Both diagnosis and management commonly use ambulatory blood pressure monitoring; results correlate more strongly with cardiovascular diseases death than office monitoring. We evaluated values their variability from hour to see if when they differed between hypertensive patients without obesity. The study included 1345 who underwent 24 h monitoring then were divided into groups according body mass...

Mechanisms of transmesothelial invasion ovarian cancer are still poorly understood. Here we examined whether this phenomenon may be determined by an expression intercellular junctions in peritoneal mesothelial cells (PMCs). Analysis tumors showed that localized below intact layer PMCs. The PMCs located near the invaded displayed low connexin 43, E-cadherin, occludin, and desmoglein, as well expressed SA-β-Gal, a marker senescence. Experiments vitro senescent exhibited decreased levels four...

Abstract Background Coronavirus disease (COVID-19) may lead to serious complications and increased mortality. The outcomes of patients who survive the early period are burdened with persistent long-term symptoms morbidity aim our study was determine which baseline parameters provide best prediction outcomes. Methods group comprised 141 hospitalized for COVID-19. Demographic data, clinical data laboratory were collected. main endpoints defined as in-hospital mortality 1-year associations...

A T I O N Inflammation in coronary artery ectasia 713patients with CAE compared patients and without significant atherosclerosis, using endocan simple inflammatory metabolic markers.Methods In this study, we consecutively enrolled 27 (CAE group) out of who underwent angiography for suspected CAD.The diagnosis was based on the conventional definition a dilation to diameter 1.5 times or more adjacent normal segment.The second group included age-and sex -matched stenosis greater than 70% (CAD...

Background: Coronary artery atherosclerosis development and progression are related to generic, clinical, lifestyle factors combined with inflammatory activation. The relationship between trace element concentration morbidity is under investigation gain a clearer understanding of underlying pathological processes. Methods: Thirty-five consecutive patients (22 males 13 females) median [interquartile range (IQR)] age 67 (61–73) years presenting anginal symptoms were included in the single...

The present study aimed to evaluate the plasma concentration of pro and antiangiogenic factors their role in pathogenesis coronary artery abnormal dilation (CAAD). We measured matrix metalloproteinase-8 (MMP-8), transforming growth factor beta 1 (TGF-β1), Angiopoietin-2, vascular endothelial (VEGF), fibroblast (FGF) using a sandwich ELISA technique patients with (CAAD, Group 1), disease (CAD, 2), normal arteries (NCA, 3). Patients suffering from CAAD showed significantly higher...

Inflammation and angiogenesis disturbances are considered as factors contributing to the development of coronary artery ectasias (CAE). Endocan (endothelial cell-specific molecule-1 - ESM-1) regulates both inflammatory angiogenetic processes. However, there no data about correlation between endocan level severity CAE measured with total volume dilation.To assess whether process concentration correlates CAE.We selected prospectively a 43 consecutive patients ectasia from 2240 who underwent...

A 52-year-old female was admitted to the Department of Hypertension with resistant hypertension coexistent type 2 diabetes mellitus, two episodes transient ischaemic attack in past, and obesity. The patient’s arterial uncontrolled on 6 antihypertensive medications, which included a loop diuretic an aldosterone antagonist. During course previous hospitalisation, secondary excluded. Angio-computed tomography (CT) results showed bilateral double renal artery diameter main trunks more than 4 mm...

Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity spontaneously drug-inducible senescent ovarian cells. Experiments were performed on tumors tumor-derived primary epithelial cells (pEOCs) that obtained from chemotherapy-naïve patients who received carboplatin (CPT) paclitaxel (PCT) before cytoreduction.The analysis showed present in both groups, albeit most frequently covering a greater area tissues chemotherapy-positive women....

To understand the mechanism underlying coronary artery abnormal dilatation (CAAD), present study identified and compared expression of circulating microRNAs (miRNAs) in three groups patients. Group 1 included 20 patients with CAAD, 2 angiographically confirmed disease (CAD), 3 normal arteries (control). miRNAs were isolated from plasma samples profiled using PCR arrays miRCURY LNA Serum/Plasma Focus Panels. The demonstrated that miRNA levels significantly different (fold change >2...

2018 ESC/ESH guidelines have recommended 24-h ambulatory blood pressure monitoring to assess hypotensive therapy in many circumstances. Recommended target office measurements is between 120/70 and 130/80 mmHg. Such targets for lacks. We aimed define values of hypertensive patients. Office data were collected from 1313 patients sorted following increasing systolic (SBP)/diastolic (DBP) measurements. The corresponding calculated. Values mmHg correspond monitoring: night-time SBP/DBP mean:...

A 52-year-old woman was admitted to the Department of Hypertension with resistant hypertension coexistent type 2 diabetes mellitus, two episodes transient ischaemic attack in past, and obesity.The patient's arterial uncontrolled on six antihypertensive medications.A denervation procedure Simplicity cathether (Medtronic) applied.In main left renal artery, ablations were performed without any complications.During first ablation right oedema wall a significant stenosis 80% occurred.Due above,...

Tomasz Urbanowicz et al., LUCs as co-existence CAD predictors in SA patients characterized by LUCs.The impossibility of evaluating the potential influence anti-inflammatory effect statins and antidiabetic treatment may be a limitation our study.In conclusion, LUC count above 0.19 K/μl whole blood analysis can regarded an indicator for possible co-exitance coronary artery disease with aortic stenosis.

Awakening and growth reinitiation by dormant cells may contribute to epithelial ovarian cancer (EOC) relapse. The links between these phenomena are loose because of the limited stock compelling models EOC dormancy. Here, we show a simple convenient dormancy research protocol based on serum starvation. This study was conducted established cell lines A2780, OVCAR-3, SKOV-3, as well primary cells. Cell arrest proliferation were monitored assessing Ki67 antigen, PKH26 fluorescence, cycle...

Background: The coronary artery disease (CAD) remains the leading cause of morbidity that is characterized by broad spectrum symptoms. Up to 30% performed angiographies reveal normal arteries. aim study was find simple predictor for significant epicardial stenosis among patients with chronic syndrome. Methods: There were 187 (131 (709%) men and 56 (30%) women) in median (Q1–Q3) age 67 [58–72] presenting stable CAD symptoms enrolled into present retrospective analysis. demographical, clinical...

Anomalies of coronary arteries are rare (about 0.3-1.3% patients undergoing a angiography procedure), and left artery (LCA) going from the right sinus Valsalva (RSV) is described in 0.09-0.15% cases.We present case 61-year-old female who complained typical angina symptoms for two years.A cardiac stress test was performed with positive result.The patient admitted to hospital catheterisation.Electrocardiogram (ECG) revealed: rhythm 66/min,

Objective: The objective of the study was to assess hypotensive effect and safety add-on therapy with aldosterone inhibitor – eplerenone in patients resistant arterial hypertension. Design method: 50 office systolic (SBP) diastolic blood pressure (DBP) still exceeding 140 mmHg 90 respectively, despite being treated at least 3 drugs, including diuretic who did not have history inhibitors treatment last months were enrolled this study. 28 mean during daytime greater than 135/85 mmHg, potassium...