A5007127999- Inflammatory Bowel Disease
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Microscopic Colitis
- Infectious Diseases and Tuberculosis
- Viral-associated cancers and disorders
- Gut microbiota and health
- Gastrointestinal disorders and treatments
- Anesthesia and Pain Management
- Diverticular Disease and Complications
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- RNA Research and Splicing
- Pain Management and Opioid Use
- Liver physiology and pathology
- Liver Disease and Transplantation
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Cytomegalovirus and herpesvirus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Ruminant Nutrition and Digestive Physiology
- Cutaneous lymphoproliferative disorders research
- Peripheral Nerve Disorders
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Central South University
2014-2023
Second Xiangya Hospital of Central South University
2003-2023
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Xiangya Hospital Central South University
2010-2014
OBJECTIVES: Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate novel nomogram for differentiating them. METHODS: In total, 310 eligible patients were recruited 6 tertiary inflammatory bowel centers. Among them, 212 consecutive (143 CD 69 ITB) used in the derivation cohort establishment of equation nomogram; 7 investigative modalities including clinical...
Malnutrition is prevalent among patients with inflammatory bowel disease (IBD). Nutritional profiles Asian IBD have seldom been investigated. We assessed the prevalence of and risk factors for malnutrition, use nutrition support, sociopsychological status associated malnutrition in China.Patients ulcerative colitis Crohn's (CD) recruited from 43 tertiary referral hospitals were screened nutrient deficiencies this cross-sectional study. The support was recorded. by subjective questionnaires....
Aim To analyze the changes of different Lactobacillus species in ulcerative colitis patients and to further assess therapeutic effects selected strains on dextran sulfate sodium (DSS)-induced experimental BALB/c mice. Methods Forty-five active (UC) 45 population-based healthy controls were enrolled. Polymerase chain reaction (PCR) amplification real-time PCR performed for qualitative quantitative analyses, respectively, UC patients. Three from three colitis. Sixty 8-week-old mice divided...
The internal environment of the gallbladder has been considered extremely unfavorable for bacterial growth, and microbial profile still unknown. By high-throughput sequencing 16S rRNA gene, we studied from healthy rabbits before after weaning. Moreover, investigated difference microbiota between gut. Our results showed that was dominantly populated by Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria in phylum throughout developmental stages rabbits. adult higher species richness...
This study aimed to investigate the effects of ultrasound-guided bilateral parasternal block (PSB) combined with rectus sheath (RSB) on postoperative recovery quality in patients undergoing median sternotomy for cardiac surgery. Eighty were randomly assigned either intervention group (receiving PSB + RSB, n = 40) or control (not receiving 40). The primary outcome was opioid consumption within first 24 h postoperatively. Secondary outcomes included Visual Analog Scale (VAS) pain scores and...
Colorectal carcinoma (CRC) is one of the most common cancers in world, and identification new CRC biomarkers will be helpful for diagnosis treatment CRC. For isobaric tags relative absolute quantitation (iTRAQ) analysis, fresh adjacent, colonic adenoma, ulcerative colitis, Crohn's disease, noncancerous epithelial tissue were obtained from patients at 2nd Xiangya Hospital Central South University, China. The function heterogeneous nuclear ribonucleoprotein M (HnRNP M) during proliferation,...
Abstract Background Ustekinumab (UST) was approved in China for moderate-to-severe Crohn’s disease (CD) 2020. The prevalence rates of tuberculosis and hepatitis B virus (HBV) infection are high China, no guideline clearly states that chemoprophylaxis or prophylactic anti-HBV therapy should be prescribed before UST administration. This study aimed to assess the risk HBV reactivation CD patients with latent (LTBI) previous receiving UST. Methods A multicenter retrospective cohort carried out...
This study investigated resident microbiota in the whole gastrointestinal (GI) tract to explore gut development early life and found that early-life antibiotic exposure exacerbated alterations murine dextran sulfate sodium (DSS)-induced colitis. Furthermore, presence of bacteria GI mice before birth importance lactation period were confirmed.
We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, possible correlations among molecular findings, phenotype, clinical features, outcome.We investigated 181 paraffin-embedded B-cell lymphoma samples using immunohistochemistry in situ hybridization.The levels Ki67, LSH, 5-hmC, E2F1 were all increased germinal center lymphomas when compared with those normal lymph nodes, LSH was highly expressed diffuse large...
Ulcerative colitis is a remitting and relapsing chronic inflammatory disorder of the colon with mortality rate 7% from acute severe UC.A retrospective study correlation clinical indicators, laboratory endoscopical features, histological features severity UC was conducted in 125 cases.Diarrhea, mucous pus stool, fever, anemia, weight loss tachycardia symptoms erythrocyte sedimentation rate, concentrations C-reactive protein, amount white blood cells platelets, positive occult test positively...
Endoscopic disease activity monitoring is important for the long-term management of patients with ulcerative colitis (UC), there currently no widely accepted non-invasive method that can effectively predict endoscopic activity. We aimed to develop and validate machine learning (ML) models predicting it, which are desired reduce frequency examinations related costs.The a diagnosis UC in two hospitals from January 2016 2021 were enrolled this study. Thirty nine clinical laboratory variables...
The present case report details a rare of osteoporosis as the initial manifestation Crohn's disease (CD). A 43-year-old male was referred to Second Xiangya Hospital Central South University (Changsha, China) for further examination low back pain (LBP) without digestive symptoms. Bone mineral density (BMD) analysis indicated osteoporosis, particularly in lumbar spine. Endoscopy revealed an inflamed and strictured ileocecal valve with less inflammation ascending, transverse colon, sigmoid...
Abstract Background Inflammatory bowel disease (IBD) is rising in China, and the tendency for lifelong recurrence decreases patients’ quality of life. However, no studies on treatment decision-making Chinese patients with IBD exist. Thus, this study aimed to determine actual ideal decision-making, as well factors affecting patients. Methods A multicenter online questionnaire was distributed among diagnosed IBD. To assess that influence univariate multivariate logistic regression analyses...
Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm originating from the follicular cells in lymphoid follicles. Current knowledge on its pathogenesis limited and a well-defined treatment required. The main channel through which clinicians obtain practical information FDCS via studying published case reports. To enrich existing available literature enhance understanding of this disease, present study describes with extensive lymph node involvement 65-year-old male patient...
Abstract Rationale: Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (LPD) usually occurs in children and young adults. Gastrointestinal involvement is rare. EBV-associated manifesting as intestinal ulcers poses diagnostic challenges clinically pathologically because of the atypical manifestations. We concluded that some indicators according to our case literatures, which might be helpful diagnosis LPD manifested ulcers. Patient concerns: Here we present a 26-year-old...
To evaluate the effect of thiazovivin, a novel ROCK inhibitor, on morphology and function human corneal endothelial cells(HCECs).The primary HCECs were identified by light microscopy immunofluorescence staining neuron-specific enolase. screen optimal concentration action time thiazovivin for maintaining HCECs, Na (+)/K (+)-ATPase N-cadherin chosen as indicators, in various concentrations(0 μmol/L, 2 4 6 μmol/L)for different durations(24 h 48 h)were examined experiments. The expression was...
To understand the value of Child-Pugh (CP) classification and model end-stage liver disease (MELD) score for patients with cirrhosis their prognosis by retrospectively analyzing two methods in hemorrhage death non-hemorrhage cirrhosis.A total 72 who died (the group) were analyzed retrospectively, initial data hospital before collected. The information control group (88 patients) at same time was also obtained. divided into subgroups: esophagus varicosity burst massive group.MELD CP...
Objective To unify the definitions of colonoscopic characteristics Crohn disease （CD） and intestinal tuberculosis （ITB）, to evaluate colonoseopie clinical features in differential diagnosis CD ITB. Methods A collaborative group composed 10 experts from 5 hospitals voted identify confirm characteristics. Clinical were ana- lyzed, thereafter, scored based on different diagnostic specificity. ROC curve was used for determining cutoff point differentiate Results Firstly, standard endoscopic...