A5019878183- Veterinary Oncology Research
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Proteoglycans and glycosaminoglycans research
- Sarcoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Nasolacrimal Duct Obstruction Treatments
- Digestive system and related health
- Cancer, Hypoxia, and Metabolism
- Infectious Diseases and Mycology
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Influenza Virus Research Studies
- Cancer Diagnosis and Treatment
- Microbial infections and disease research
- CRISPR and Genetic Engineering
- Hedgehog Signaling Pathway Studies
- Pluripotent Stem Cells Research
- Corneal Surgery and Treatments
- Lymphatic Disorders and Treatments
- Veterinary Medicine and Surgery
- Soft tissue tumor case studies
Seoul National University
2015-2025
University of Veterinary Medicine
2021
Samsung (South Korea)
2017
The osteochondrogenic switch of vascular smooth muscle cells (VSMCs) is a pivotal cellular process in atherosclerotic calcification. However, the exact molecular mechanism transition VSMCs remains to be elucidated. Here, we explore regulatory role TXNIP (thioredoxin-interacting protein) phenotypical transitioning toward responsible for calcification.The phenotypes Txnip-/- mice were analyzed combination with single-cell RNA-sequencing. Tagln-Cre; Txnipflox/flox (smooth cell-specific Txnip...
Valvular inflammation triggered by hyperlipidemia has been considered as an important initial process of aortic valve disease; however, cellular and molecular evidence remains unclear. Here, we assess the relationship between plasma lipids valvular inflammation, identify association low-density lipoprotein with increased lipid macrophage accumulation. Single-cell RNA sequencing analysis reveals heterogeneity leukocytes, interstitial cells, endothelial their phenotypic changes during leading...
This study aimed to design and evaluate a novel trans-bleb device (TBD) for draining aqueous humor trapped within fibrotic blebs following Ahmed glaucoma valve (AGV) implantation in dogs. Two clinically normal, purpose-bred Beagles underwent AGV surgery one eye. When bleb was formed with increased intraocular pressure (IOP), the TBD inserted through fenestration created bleb. IOP measurements, slit-lamp biomicroscopic ultrasound (UBM) evaluations were performed during follow-up. Results...
An 11-year-old castrated male Turkish Angora cat presented with chronic lethargy and inappetence was diagnosed non-regenerative anemia, increased nucleated red blood cells, thrombocytopenia. Tests for anemia-related infections were negative. Imaging revealed pleural effusion, hepatomegaly, splenomegaly, enlarged abdominal lymph nodes, raising suspicion of a round cell tumor in the spleen. His anemia effusion did not improve despite chemotherapy cytarabine administration. Erythroid precursor...
Several clinical studies have reported increased expression of osteopontin (OPN) in various types human cancer, including gastric cancer. However, the precise mechanisms underlying tumor development remain unclear. In present study, we investigated pathogenic roles OPN Helicobacter pylori-induced cancer development. Wild-type (WT) and knockout (KO) mice were treated with N-methyl-N-nitrosourea (MNU) infected H.pylori. Mice killed 50 weeks after treatment, stomach tissues assessed by...
// Su-Hyung Lee 1 , Jun-Won Park 2 Sang-Ho Woo Du-Min Go Hyo-Jung Kwon 3 Ja-June Jang 4 Dae-Yong Kim Department of Veterinary Pathology, College Medicine, Seoul National University, 151-742, South Korea Biomolecular Function Research Branch, Cancer Center, Goyang, Gyeonggi 410-769, Chungnam Daejeon 305-764, 110-799, Correspondence to: Kim, email: daeyong@snu.ac.kr Keywords: osteopontin, EGFR, c-Jun, apoptosis, hepatocellular carcinoma Received: April 29, 2016 Accepted: November 01,...
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed PB2, PB1, and PA. PB2 plays role in overcoming the host barrier; however, genetic prerequisites for to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified prototypic that conferred non-replicative non-pathogenic traits PR8-derived recombinant when it was used infect mice. Here, demonstrated key amino acid (I66M, I109V, I133V, collectively referred as MVV) this increase...
Abstract A 12‐year‐old castrated male Shih‐Tzu dog was referred for uncontrolled glaucoma and uveitis with highly pigmented sclera, in both eyes (OU). On ophthalmic examination, the menace response, dazzle reflex pupillary light were negative OU. The intraocular pressure 27 mmHg right eye (OD) 70 left (OS) despite administration of antiglaucoma eyedrops. Ultrasound biomicroscopy revealed a closed ciliary cleft Ocular ultrasonography hyperechoic materials vitreous OU retinal detachment OS....
Age-associated molecular changes are deleterious and causally linked with aging may affect life span through diet.
To assess the characteristics of blebs formed after Ahmed glaucoma valve (AGV) surgery in dogs using ultrasound biomicroscopy (UBM) and to analyze their correlation with postoperative intraocular pressure (IOP).
Here, we examined the effects of BMP signaling pathway inhibitor LDN-193189 on pluripotency porcine embryonic stem cells (ESCs) in absence feeder using molecular and transcriptomic techniques. Additionally, some extracellular matrix components ESC were evaluated to develop an optimized sustainable feeder-free culture system for ESCs. Feeder found play important role supporting ESCs by blocking trophoblast mesodermal differentiation through inhibition pathway. treatment with LDN-193189,...
A six-year-old castrated male Maltese dog presented to a private animal clinic with mass on the dog's lower lip without any other clinical signs. The (3 × 2 cm) was whitish and grossly well circumscribed, histopathological examination revealed that composed of normal cartilage tissue surrounded by fibrous connective tissues. Based gross findings, histopathology anatomical location mass, first diagnosis cartilaginous choristoma in made.
A 3.9-year-old female African pygmy hedgehog (Atelerix albiventris) had a firm, tan-colored mass with an uneven surface arising from the mandibular salivary gland. histopathologic examination revealed that was composed of neoplastic proliferation epithelial and spindle cells. The cells showed positive for vimentin, smooth muscle actin, calponin cytokeratin 14 and, negative 19, suggesting were derived myoepithelial Based on histological findings immunohistochemistry results, diagnosed as...
Here, we report pig embryonic stem cells (ESCs) originating from parthenogenetic blastocysts which were developed 2-cell embryos micro-injected with porcine OCT4 reporter system cultured in previous reported chemically defined culture media. The ESCs expressed pluripotency markers and fluorescent signals produced by system. Also, they capable of forming teratomas following subcutaneous injection into nude mice. Since enables the non-destructive classification condition live pluripotent...
Myung-Chul Kim, Du-Min Go, Sang-Ho Woo, Jeong-Seop Oh, Dae-Yong Na-Yon Yeseul Yang, Jae-Ha Jung, Hwa-Young Youn, Yongbaek Kim. J Vet Clin 2023;40:387-92. https://doi.org/10.17555/jvc.2023.40.5.387
Abstract Background A 10‐year‐old castrated male Maltese dog was presented with chronic swelling that had been present for at least 5 years in the medial canthus of right eye (OD). Objectives To describe treatment outcome dacryops dacryolithiasis. Methods Bilateral patency nasolacrimal system confirmed by flushing both upper and lower puncta. Ocular ultrasonography revealed a well‐defined, oval‐shaped, heterogeneous mass several hyperechoic foci. Dacryocystorhinography no connection between...
Two Whooper swan (Cygnus cygnus) died after suffering from pododermatitis, lethargy, and ataxia; necropsy was performed.Grossly, the liver swollen firm.The kidney spleen were also enlarged a pale tan color.On histopathologic examination with Congo red staining, amyloidosis noted in liver, spleen, kidney.In addition, marked osseous metaplasia present liver.Based on these results, systemic involving diagnosed.Study results indicate that an inflammatory reaction associated pododermatitis had...
A 7-year-old Maltese was presented to a veterinary clinic for history of anorexia, soft feces, and anemia. During abdominal sonography computed tomography imaging, splenic mass suspected. Laparotomy revealed the bloody ascites, enlarged spleen containing large spherical mass. Microscopically, parenchyma replaced by neoplastic cells with cytoplasmic vacuolation abundant myxoid matrix. Cellular matrix were positive Oil-Red-O Alcian-blue stains. The vimentin on immunohistochemistry. case...