A5113764394- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Diet and metabolism studies
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Digestive system and related health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Exercise and Physiological Responses
- Advances in Oncology and Radiotherapy
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Gestational Diabetes Research and Management
- Chronic Disease Management Strategies
- Non-Invasive Vital Sign Monitoring
- Neurogenetic and Muscular Disorders Research
- Hormonal and reproductive studies
- Glioma Diagnosis and Treatment
Yale University
2011-2025
Yale New Haven Hospital
2011-2015
Harvard University
2013-2014
Beth Israel Deaconess Medical Center
2013-2014
Neurology, Inc
2008
Studies have evaluated acute kidney injury (AKI) using biomarkers in various settings, but their prognostic utility within current practice is unclear. Thus, we sought to determine the of newer or traditional markers (fractional excretion sodium [FeNa] and urea [FeUrea] microscopy) over clinical assessment alone.This a prospective cohort study adults on first day meeting AKI criteria. We measured urine concentrations neutrophil gelatinase-associated lipocalin (NGAL), molecule-1 (KIM-1),...
Serious cardiac arrhythmias have been described in approximately 5% of patients after subarachnoid hemorrhage (SAH). The aim this study was to identify the frequency, risk factors and clinical impact arrhythmia SAH. We prospectively studied 580 spontaneous SAH identified complications associated with development clinically significant arrhythmia. Multiple logistic regression analysis used calculate adjusted odds ratios for effect on hospital 3-month outcome, as measured by modified Rankin...
Abstract Context Transgender men (TGM) are persons assigned female gender at birth with a male identity and routinely treated testosterone. Androgen excess is associated endothelial dysfunction among cisgender females (CGF) an early sign of atherosclerosis hypertension. Objective To determine the effect testosterone treatment on function in TGM. Setting The John B. Pierce Laboratory Yale School Medicine. Subjects Eleven TGM (age 27 ± 5 years; BMI 24.4 3.7 kg/m 2 ) receiving (T) 20 CGF (28...
Background: Severe hypertriglyceridemia (triglycerides (TGs) >1000 mg/dL, >11.3 mmol/L) is a rare but potentially morbid condition in pregnancy. Physiological changes pregnancy may unmask or exacerbate an underlying defect TG metabolism. When conventional therapies are ineffective controlling levels, personalized management approach needed. We present case of severe hypertriglyceridemic pancreatitis successfully managed with niacin, treatment that has seen limited use due to the...
Abstract Background EBRT in resected, nonmetastatic anaplastic thyroid cancer (ATC) remains undefined. We evaluated patterns/outcomes with and chemotherapy this setting. Methods This retrospective analysis included patients identified from the National Cancer Database ATC 2004 to 2014 who underwent non‐palliative resection. Results Our 496 patients, including 375 adjuvant (among whom 198 received concurrent chemotherapy). The median age was 68 years. On MVA, associated sex (OR 0.5, 95% CI...
Irisin, secreted by skeletal muscle and possibly fat, is hypothesized to play an important role in modulating energy expenditure, obesity metabolism. Coffee consumption also increases expenditure leads positive metabolic effects, but whether these effects are mediated irisin remains unknown. The objective of this study was determine the association between baseline levels profile humans investigate caffeinated coffee alters levels. To end, a secondary analysis performed investigating at...
Seizures in patients with pituitary pathology are uncommon and typically secondary to electrolyte disturbances. Rarely, seizures have been described from mass effect related large prolactinomas undergoing medical treatment. We describe a 54 year-old male who presented first-time generalized seizure, macroadenoma compressing the left temporal lobe. His abated after endoscopic endonasal debulking of tumor. This report highlights isolated as potential sole presenting symptom macroadenomas...
Objective: Rickets can be caused by a wide variety of underlying nutritional deficiencies or genetic defects. There is significant overlap in the clinical presentations various forms rickets and risk for misdiagnosis great. This report describes diagnostically challenging case that highlights important differences between two demonstrates how gene sequencing technology instrumental identification further characterization these diseases.Methods: A patient diagnosed with X-linked...
Abstract Introduction Congenital hypopituitarism is a rare and potentially devastating disorder occurring in 1 4000 to 10,000 live births. can occur due mutations transcription factors signaling molecules involved the embryologic development of pituitary. In small number cases there family history disorder. these cases, multiple genes have been implicated including HESX1, PROP1, POU1F1, LHX3, LHX4, SOX2, SOX3, OTX2, PAX6, FGFR1, GLI2, FGF8 with different forms inheritance. However, majority...