A5051239618- Eicosanoids and Hypertension Pharmacology
- Genomics and Chromatin Dynamics
- Antioxidant Activity and Oxidative Stress
- Heme Oxygenase-1 and Carbon Monoxide
- Atherosclerosis and Cardiovascular Diseases
- Tannin, Tannase and Anticancer Activities
- Animal Virus Infections Studies
- Aquaculture disease management and microbiota
- Engineering Education and Curriculum Development
- Acute Kidney Injury Research
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Organ and Tissue Transplantation Research
- Reproductive Biology and Fertility
- Advanced Glycation End Products research
- Viral gastroenteritis research and epidemiology
- Reconstructive Facial Surgery Techniques
- Tea Polyphenols and Effects
- Adenosine and Purinergic Signaling
- Dam Engineering and Safety
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Metabolomics and Mass Spectrometry Studies
Guangxi University of Chinese Medicine
2023-2024
First Affiliated Hospital of Xiamen University
2017-2021
Southwest Jiaotong University
2020-2021
Institute of Rock and Soil Mechanics
2018
Hefei University of Technology
2018
Tianjin University of Technology
2013
Hebei Normal University
2013
Endothelial dysfunction is involved in the pathophysiological processes of contrast media (CM)–induced acute kidney injury (CI-AKI) after vascular angiography or intervention. Previous study found that apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, alleviates endothelial impairments via upregulating heme oxygenase-1 (HO-1) expression and scavenging excessively generated reactive oxygen species (ROS). However, whether D-4F could ameliorate oxidative injuries cells through suppressing ROS...
The Qianjiangping landslide is the first large-scale rock slide in Three Gorges Reservoir (TGR) Area, China, after impoundment of TGR. Previous studies on slope showed that most researchers agreed reservoir and rainfall were two main triggering factors failure. However, there different views about influence degrees In order to clarify each three conditions (reservoir impoundment, rainfall, combined effect rainfall) failure reveal mechanism slope, underground water tables stresses calculated...
Apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, exhibits anti-atherogenic effects similar to high-density lipoprotein (HDL). However, it remains elusive whether D-4F and HDL share molecular mechanisms underlying endothelial cell protections. We here compared the metabolic changes in cells induced by against oxidized low-density (ox-LDL), which may be of benefit understanding protective D-4F. Functional assays including wound healing, transwell migration tube formation were used evaluate...
In type 2 diabetes mellitus (T2DM), high-density lipoprotein (HDL) impairs its anti-atherogenic properties and even develops to a pro-inflammatory pro-atherogenic phenotype because of abnormal compositions modifications. this study, we examined the effects related mechanisms glycation HDL on proliferation migration vascular smooth muscle cells (VSMCs).Glycated (G-HDL) was modified with D-glucose (25 mmol/L) in vitro. Diabetic (D-HDL) isolated from T2DM patients. Rat VSMCs were thoracic...
Enhancers are cis-regulatory DNA elements that positively regulate the transcription of target genes in a tissue-specific manner and dysregulation various diseases such as cancer. Recent studies showed enhancers can miRNAs participate biological synthesis miRNAs. However, network enhancer-regulated across multiple cancers is still unclear. Here, total 2,418 proximal enhancer-miRNA interactions 1,280 distal were identified through integration genomic distance, co-expression, 3D genome data 31...
Abstract D‐4F, an apolipoprotein A‐I (apoA‐I) mimetic peptide, possesses distinctly anti‐atherogenic effects. However, the biological functions and mechanisms of D‐4F on hyperplasia vascular smooth muscle cells (VSMCs) remain unclear. This study aimed to determine its roles in proliferation migration VSMCs. In vitro , inhibited VSMC induced by ox‐LDL a dose‐dependent manner. up‐regulated heme oxygenase‐1 (HO‐1) expression VSMCs, PI3K/Akt/AMP‐activated protein kinase (AMPK) pathway was...
Enhancers can act as cis-regulatory elements to control transcriptional regulation by recruiting transcription factors (TFs) in a distance and orientation-independent manner. However, it is still unclear how p53 participates the enhancer network TF hepatic carcinoma under condition of DNA damage. A total 14,286 activate enhancers were identified through integration stable unstable RNAs (eRNAs) captured CAGE GRO-seq, respectively. Furthermore, 218 p53-bound (Enhp53) analyzing ChIP-seq HepG2...
For the insufficient of students' innovative ability and employment caused by imbalance between theory teaching practice in process applied undergraduate majors' personnel training, author introduced a talent cultivation paths - training mode based on combination professional programmatic accreditation double certificates under background university-industry cooperation. The purpose is to promote balanced development teaching. Then, operation mechanism was discussed from three aspects:...
Abstract Enhancers are often mutated and dysregulated in various diseases such as cancer. By integrating the function annotation of mammalian genome (FANTOM) enhancers expression profiles RNA-seq data from The Cancer Genome Atlas (TCGA) 13 cancers their corresponding para-cancerous tissues, we systematically identified a total 4702 significantly differentially expressed (DE) enhancers. Furthermore, 1036 DE genes regulated by were identified. It was found that these cancers, most (61.13%)...
Objective To explore the effect of exposed therapy in wound nursing after skin flap transplantation for lower extremity injury. Methods During January and August 2012, forty three patients, who underwent injuries with soft tissue defect whose wounds were bandaged using conventional gauze bandaging therapy, enrolled as control group. From September 2012 to April 2013, two patients applied when dressings removed during 6 8 hours surgery intervention This study aimed evaluate bandage by...