A5026816218- Influenza Virus Research Studies
- interferon and immune responses
- Flavonoids in Medical Research
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Phytochemistry and Bioactive Compounds
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and biological activities of Ficus species
- Ginger and Zingiberaceae research
- Tryptophan and brain disorders
- Hepatitis C virus research
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Pharmacological Receptor Mechanisms and Effects
- Cytomegalovirus and herpesvirus research
- Click Chemistry and Applications
Shandong University of Traditional Chinese Medicine
2023-2025
Seasonal or pandemic illness caused by influenza A viruses (IAVs) is a major public health concern due to the high morbidity and notable mortality. Although there are several approved drugs targeting different mechanisms, emergence of drug resistance calls for new candidates that can be used alone in combinations. Small-molecule IAV entry inhibitor, ING-1466, binds hemagglutinin (HA) blocks HA-mediated viral infection. Here, we show this inhibitor demonstrates preventive therapeutic effects...
Previous studies reported the latex from fruit of Ficus carica L. (fig) has anti-tumor and antioxidant activities in animal models. However, its active constituents, mechanism action, safety remain unknown. The alcohol-precipitated fraction fig (AFFL) was purified prepared for testing against non-small cell lung cancer (NSCLC). UPLC-TOF-MS/MS used to examined components AFFL. We validated efficacy by researching antitumor phenotypes vitro constructing subcutaneous grafts nude mice with...
Respiratory syncytial virus (RSV) causes lower respiratory tract diseases and bronchiolitis in children elderly individuals. There are no effective drugs currently available to treat RSV infection. In this study, we report that Licochalcone A (LCA) can inhibit replication mitigate RSV-induced cell damage vitro, LCA exerts a protective effect by reducing the viral titer inflammation lungs of infected mice vivo. We suggest mechanism action occurs through pathways antioxidant stress...
Influenza A virus (IAV) poses a global public health concern and remains an imminent threat to human health. Emerging antiviral resistance the currently approved influenza drugs emphasizes urgent need for new therapeutic entities against IAV. Allopregnanolone (ALLO) is natural product that has been as antidepressant drug. In present study, we repurposed ALLO novel inhibitor IAVs. Mechanistic studies demonstrated inhibited replication by interfering with nucleus translocation of viral...
Ethnopharmacological relevance: Qingjin Huatan Decoction (QJHTT) consists of 11 herbal medicines: Scutellaria baicalensis Georgi, Gardenia jasminoides J.Ellis, Platycodon grandiflorus (Jacq.) A.DC., Ophiopogon japonicus (Thunb.) Ker Gawl., Morus alba L., Fritillaria thunbergii Miq., Anemarrhena asphodeloides Bunge, Trichosanthes kirilowii Maxim., Citrus reticulata Blanco, Poria cocos (Schw.) Wolf, and Glycyrrhiza uralensis Fisch. As a traditional compound Chinese medicinal formula, QJHTT has...
Influenza A viruses (IAVs) have gradually developed resistance to FDA-approved drugs, which increases the need discover novel antivirals with new mechanisms of action. Here, we used a phenotypic screening strategy and discovered that imidazo[1,2-a]pyrazine derivative A4 demonstrates potent broad-spectrum anti-influenza activity, especially for oseltamivir-resistant H1N1/pdm09 strain. Indirect immunofluorescence assays revealed induces clustering viral nucleoprotein (NP) prevents its nuclear...