A5100435828- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Oral microbiology and periodontitis research
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Cholesterol and Lipid Metabolism
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Microbial Metabolic Engineering and Bioproduction
- Inorganic Fluorides and Related Compounds
- Urinary Bladder and Prostate Research
- Acute Lymphoblastic Leukemia research
- Luminescence Properties of Advanced Materials
- Proteoglycans and glycosaminoglycans research
- Corrosion Behavior and Inhibition
- Electrospun Nanofibers in Biomedical Applications
- Chemical Reactions and Isotopes
- Supercapacitor Materials and Fabrication
- Advancements in Battery Materials
- Muscle metabolism and nutrition
- Nerve injury and regeneration
- Retinoids in leukemia and cellular processes
- Enzyme Catalysis and Immobilization
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Zhejiang Gongshang University
2024-2025
Hospital of Hebei Province
2024
Jilin University
2007-2024
Anhui University of Traditional Chinese Medicine
2013-2023
Guangzhou University of Chinese Medicine
2021
Southern Medical University
2017
Nanfang Hospital
2017
Beihang University
2017
Background Acute lymphoblastic leukemia (ALL) is a common cancer in children and adolescents, severely affecting their survival health. With the discovery of new drugs improved treatment options, rate ALL adolescents has significantly. Methods We used GBD (global burden disease) database to collect patients aged 0–19 years (0–5 years, 5–9 10–14 15–19 years) diagnosed with between 1990 2021. Disease status change were analyzed by learning about prevalence, death, incidence, DALYs...
Introduction: Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation. Methotrexate one of the most effective drugs for rheumatoid arthritis, but adverse reactions caused oral methotrexate greatly limit its clinical application. Transdermal drug delivery system ideal alternative to absorbing into human body through skin. However, in existing microneedles mostly used alone, and there are few reports combined use with other anti-inflammatory drugs. Methods: In...
Periodontitis is a multifactorial chronic infectious disease leading to host immune response involving inflammatory cytokines, especially IL-1β, which the main reason for further developing this disease. IL-1 receptor antagonist (IL-1ra) binds receptor, inhibiting IL-1β signaling and reducing levels of other cytokines closely related periodontitis, such as IL-6 TNF-α. Therefore, use IL-1ra inhibit periodontitis development in system, ensuring its sustained release, might be an effective way...
Periodontitis is a chronic inflammatory disease that considered to be the main cause of adult tooth loss. Diabetes mellitus (DM) has bidirectional relationship with periodontitis. Interleukin-1β (IL-1β) an important pre-inflammatory factor, which participates in pathophysiological process periodontitis and diabetes. The interleukin-1 receptor antagonist (IL-1ra) natural inhibitor IL-1, balance between IL-1ra IL-1β one factors affecting (CP) purpose this study develop drug carrier safe...
Biopolymers are often used in foods and pharmaceuticals as sequestrants of bile acid anions (BAAs) to reduce cholesterol. However, the vitro BAA binding effects biopolymer-based (BPBSs) corresponding structure–activity relationships have not yet been fully clarified. This review first describes structural characteristics BPBSs, including polysaccharide-based protein-derived biopolymers, well their ability. Next, underlying molecular interactions mechanisms that drive these bind BAAs...
The aim of this study was to explore the nanostructured lipid carriers as a delivery system biochanin A so supply method improve its bioavailability. Biochanin A-loaded (BCA-NLCs) were prepared by emulsion-evaporation and low temperature solidification. Pharmacokinetics carried out in rats upon oral administration at dose 10 mg/kg. BCA-NLC showed spherical formulation had mean diameter 174.68±0.96 nm, zeta potential -20.9±0.8 mv entrapment efficiency 97.36±0.14%. DSC XRD studies indicated...
The activity of lipase was inhibited or promoted by different macromolecular colloids, but the underlined general rules were not clear. In this paper, systematically analyzed in media. detailed factors that affect enzyme extracted for quantification. Three functions, including viscosity, crowding effect, and soft interactions, established to describe medium effect. parameter based on Huggins constant Kramer able characterize quality A multivariate nonlinear regression model proposed...
The purpose of this study was to design injectable polymer formulations for controlled release paclitaxel and Bovine serum albumin (BSA) using amphiphilic triblock copolymer (mPEG-b-P(OA-DLLA)-b-mPEG) consisting methoxy poly(ethylene glycol) (mPEG), poly(octadecanedioic anhydride) (POA) D,L-lactic acid oligomer (ODLLA). An aqueous dispersion mPEG-b-P(OA-DLLA)-b-mPEG nanoparticle freeze-dried powder (NP-FDP) can undergo a sol–gel–sol transition as the temperature is increased from 4 90 °C....
This study investigated the potential of targeted intestinal lymphatic transport puerarin via a lipid formulation approach. Three formulations PEG nanoemulsion, nanosuspension and an oil suspension containing were examined with lymph-cannulated anaesthetized rat model. Plasma lymph samples analyzed by HPLC. Lymph triglyceride was measured using enzymatic colorimetric technique. After 8 h, total administered dose accumulated in thoracic duct analyze. Nanoemulsion, 0.065 ± 0.006%, 0.137...
The development of controlled drug delivery systems for bone regeneration, especially microspheres, has become a research hotspot in recent years. Chitosan and its derivative O-carboxymethyl chitosan have been considered to be an effective way due their nontoxicity biodegradability. Currently, most the studies researched on synthesizing characterizing chitosan. However, few focused differences between microspheres directly. In this study, were developed by water-in-oil emulsification...
Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, oral route is a preferred administration. But, bioavailability sCT very low due to enzymatic degradation poor permeation across intestinal epithelial cells. It was aim this study investigate pharmacodynamic (PD), pharmacokinetic (PK), mucosal injury characteristic delivery system.In study, PD experiments were performed find suitable releasing region sCT, an effect absorption enhancer, optimal mass ratio...
This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using novel reformative shear precipitation procedure. In contrast to external aqueous phase used in conventional microencapsulation technique based on emulsion solvent evaporation/extraction, procedure explored this uses medium composed glycerol viscous and ethanol polymer antisolvent, which is relatively immiscible with drug. limits drug diffusion leads rapid...
A novel amphiphilic guanidyl-functionalized stigmasterol hydrochloride (GFSH) was designed and synthesized as bile salt sequestrants for cholesterol reduction. GFSH exhibited a considerable in vitro capacity binding gastrointestinal digestion alleviated hypercholesterolemia vivo. spontaneously interacted with sodium cholate via synergistic electrostatic, hydrophobic, hydrogen-bonding interactions. The effects of on serum reduction mice fed high-fat-high-cholesterol diet were explored by...