A5058071935- Cancer Cells and Metastasis
- Digestive system and related health
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive Biology and Fertility
- Hippo pathway signaling and YAP/TAZ
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Antenna Design and Optimization
- Gastrointestinal motility and disorders
- Microwave Engineering and Waveguides
- Electric Power Systems and Control
- Congenital Diaphragmatic Hernia Studies
- Proteins in Food Systems
- Antenna Design and Analysis
- Protist diversity and phylogeny
- Congenital heart defects research
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Machine Fault Diagnosis Techniques
- Ultrasound and Hyperthermia Applications
- Cell Adhesion Molecules Research
University of Helsinki
2015-2025
Broad Institute
2025
Brigham and Women's Hospital
2025
HiLIFE – Elämäntieteiden Instituutti
2021
University of Dundee
1974
Stem cells can sort mitochondria by age The renewal of tissues in aging organisms requires stem cells, which have the unusual ability to divide asymmetrically into one daughter cell that retains properties and another differentiates a particular tissue type. Katajisto et al. used photoactivated marker proteins monitor organelles stemlike from human breast their distribution cells. Most were evenly distributed, but maintained stem-cell received more newly produced fewer old ones. Science ,...
Abstract Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic segmentation movements. However, very little known about other putative roles that smooth cells may have. Here, we show be dominant suppliers BMP antagonists, which are niche factors for intestinal stem cell maintenance. Furthermore, muscle-derived render epithelium reparative fetal-like, includes heightened YAP activity. Mechanistically, find membrane-bound matrix...
Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet exact roles of specific BM components remain unclear. Here, we show that Laminin α5 (Lama5) expression specifically in luminal epithelial cells necessary normal growth during puberty, and alveologenesis pregnancy. Lama5 loss keratin 8-expressing results reduced frequency differentiation hormone receptor expressing (HR+) cells. Consequently, Wnt4-mediated crosstalk between HR+ basal compromised...
Background & AimsMicrofold cells (M cells) are immunosurveillance epithelial located in the Peyer's patches (PPs) intestine and responsible for monitoring transcytosis of antigens, microorganisms, pathogens. Mature M use receptor glycoprotein 2 (GP2) to aid transcytosis. Recent studies have shown transcription factors, Spi-B SRY-Box Transcription Factor 8 (Sox8). necessary M-cell differentiation, but not sufficient. An exhaustive set factors sufficient differentiation development a mature...
ABSTRACT Epithelial tissues undergo fetal-like cellular reprogramming to regenerate after damage 1,2 . Although the mesenchyme and extracellular matrix (ECM) play critical roles in tissue homeostasis regeneration 2–5 , their role repurposing developmental programs epithelium is unknown. To model epithelial regeneration, we culture intestinal on decellularized small scaffold (iECM), identify Asporin (Aspn), an ECM bound proteoglycan, as a mediator of reprogramming. Aspn produced by...
Abstract Microfold cells (M cells) are immunosurveillance epithelial located in the Peyer’s patches intestine responsible for monitoring and transcytosis of antigens, microorganisms pathogens. Many transcription factors, e.g., Spi-B Sox8, necessary to M cell differentiation have been described but exhaustive set factors sufficient development a mature remains elusive. Moreover, role polycomb repressive complex 2 (PRC2) as an epigenetic regulator has not yet interrogated. Here, we show that...
SUMMARY Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic segmentation movements. However, very little known about other putative roles that smooth may have. Here, we show dominant supplier BMP antagonists, which are niche factors for intestinal stem cell maintenance. Furthermore, muscle-derived can render epithelium reparative fetal-like, includes heightened YAP activity. Mechanistically, find matrix metalloproteinase MMP17,...
Paneth cell niche promotes the function of intestinal stem cells (ISCs) during reduced food intake, but how ISC activity can be boosted when availability resources is simultaneously remains unknown. Here, we show that increase in upon dietary restriction (DR) dependent on mitochondrial alanine transaminase Gpt2 cells. Metabolic tracing Alanine directly showed DR, catabolizes increased amounts to produce lactate, which transported ISCs fuel their TCA cycle. Correspondingly, inhibition lactate...