A5009750563- Nitric Oxide and Endothelin Effects
- Gallbladder and Bile Duct Disorders
- Urinary Bladder and Prostate Research
- Neuroendocrine regulation and behavior
- Sexual function and dysfunction studies
- Pain Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Nicotinic Acetylcholine Receptors Study
- Spinal Fractures and Fixation Techniques
- Hormonal and reproductive studies
- Anesthesia and Pain Management
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Adenosine and Purinergic Signaling
- Spine and Intervertebral Disc Pathology
- Asthma and respiratory diseases
- Pharmacological Effects and Assays
- Esophageal and GI Pathology
- Mycotoxins in Agriculture and Food
- Preterm Birth and Chorioamnionitis
- Neuroscience of respiration and sleep
- Pediatric Hepatobiliary Diseases and Treatments
- Essential Oils and Antimicrobial Activity
- Reproductive System and Pregnancy
- Spinal Cord Injury Research
Sivas Cumhuriyet Üniversitesi
2007-2021
Adli Tıp Kurumu
2013
Sivas State Hospital
2011
Ministry of Health
2011
Piaggio (Italy)
2008
University of Verona
2008
Gazi University
2008
Background: Breast cancer evolution and tumor progression are controlled by complex interactions between steroid receptors growth factor receptor signaling. Aberrant signaling can augment or suppress estrogen function in hormone-dependent breast cells. Thus, we aimed to investigate antitumor effects of sorafenib lapatinib alone combination on MCF-7 Materials Methods: Cytotoxicity the was tested cells XTT assays. 50, 25, 12.5 <TEX>$6.25{\mu}M$</TEX> concentrations 200, 100, 50...
To determine whether chronic renal failure (CRF) reduces nitrergic relaxant responses in a rabbit model.Ten rabbits underwent surgery to induce uraemia (CRF rabbits) and further 10 sham operation (controls). Corpus cavernosal tissue was prepared used organ-chamber experiments, with relaxation assessed against background of pre-contraction phenylephrine. At the plateau contraction, cumulative concentrations carbachol or sodium nitroprusside (SNP), test endothelium-dependent -independent...
Antibiotics may impair small bowel smooth muscle contractility and contribute to postoperative ileus. The aim of this study was compare the contractile responses ileum different agonists in guinea pigs treated with ceftriaxone (Rocephin; F. Hoffman-La Roche, Kaiseraugst, Switzerland) or ampicillin (Ampisina; Mustafa Nevzat Ilaç Sanayii AS, Istanbul, Turkey).Twenty-four adult were randomly divided into three groups. Whereas eight these received sodium (100 mg/kg per day, i.m.) for 10 days,...
Objective To examine purinergic relaxation responses in chronic renal failure (CRF) an experimental rabbit model, and thus evaluate the possible involvement of system erectile dysfunction with CRF. Materials methods The relaxant effects ATP were measured strips corpus cavernosum smooth muscle taken from control CRF rabbits. was induced New Zealand white rabbits as previously described. Penises excised 4 weeks after inducing uraemia. In organ bath controls pre‐contracted phenylephrine...
Background: The incidence of hormonal dysfunction as a cause impotence remains controversial. However, several recent studies have reported evidence abnormalities in 25–35% impotent men. Hypothyroidism has been to occur 6% Methods: In the present study, we examined nitrergic responses hypothyroidism rabbit corpus cavernosum and compared them with controls. Results: Carbachol‐induced relaxation electrical field stimulation (EFS)‐induced frequency‐dependent relaxations decreased significantly...
Drugs that inhibit the reuptake of serotonin, norepinephrine, and/or dopamine are widely used for treating depressive disorders and have emerged as effective drugs neuropathic pain. They no substantial anti-nociceptive effects but considered, with gabapentin/pregabalin, first-line pain.In this study, three different antidepressant agents were in doses to investigate their anti-hyperalgesic rat models pain using hot plate tail flick methods. mechanisms action; vilazodone hydrochloride is a...
In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary is first choice of arterial graft, second radial (RA). Unfortunately, RA spasms are a significant problem for surgical team to overcome in perioperative postoperative period. current practice, use vasodilator agents perioperatively pending graft preparation generally accepted these may be implemented topically, endoluminally or ways. Moxonidine latest second-generation, centrally acting...
Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting agents at sheep sphincter Oddi (SO) in vitro. Methods: Sheep SO rings were mounted organ baths and tested for isometric tension cGMP levels response 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene; 3-morpholinosydnonimine hydrochloride (SIN-1); BAY 41-2272 presence absence...
Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis. Highly effective reducing sensory irritation caused by some substances, strontium salts directly affect C-type nerve fibers. The aim this study was to compare efficacy mometasone furoate and chloride on early-phase symptoms rat model Wistar albino rats (n = 24) were randomly divided into three groups: group, receiving 1 μg (2 µl/site); 3% μl/site); 5% μl/site). To induce significant nasal rhinitis, 5 µmol...