A5040859768- Neonatal and Maternal Infections
- Antibiotics Pharmacokinetics and Efficacy
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Bacterial Identification and Susceptibility Testing
- Diabetes Management and Research
- Neonatal and fetal brain pathology
- Streptococcal Infections and Treatments
- Diet, Metabolism, and Disease
- Delphi Technique in Research
- Immune Response and Inflammation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cystic Fibrosis Research Advances
- Zebrafish Biomedical Research Applications
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
Erasmus MC - Sophia Children’s Hospital
2018-2024
Sint Franciscus Gasthuis
2019-2024
Erasmus MC
2021-2022
Leiden University Medical Center
2015-2020
Type 1 diabetes is believed to be an autoimmune disease associated with irreversible loss of insulin secretory function that follows a chronic progressive course. However, it has been speculated relapsing/remitting progression may occur in type diabetes.We report the case 18-year-old girl Graves' disease, inflammatory demyelinating polyneuropathy (CIDP) and multiple islet autoantibodies, presenting hyperglycaemia. Peripheral blood mononuclear cells were analysed for autoimmunity.There two...
Abstract Background There is a lack of evidence on oral amoxicillin pharmacokinetics and exposure in neonates with possible serious bacterial infection (pSBI). We aimed to describe disposition following intravenous administration provide dosing recommendations for preterm term treated pSBI. Methods In this pooled-population pharmacokinetic study, 3 datasets were combined nonlinear mixed-effects modeling. order evaluate administration, profiles different regimens simulated the developed...
Introduction High morbidity and mortality rates of proven bacterial infection are the main reason for substantial use intravenous antibiotics in neonates during first week life. In older children, intravenous-to-oral switch after 48 hours therapy has been shown to have many advantages is nowadays commonly practised. We, therefore, aim evaluate effectiveness, safety cost-effectiveness an early with a probable infection. Methods analysis We present protocol multicentre randomised controlled...
Data published on the oral clavulanic acid pharmacokinetics in pediatric population is lacking. This research aimed to describe disposition following and intravenous administration provide insights into exposure based threshold concentrations for (pre-)term neonates infants. pooled pharmacokinetic study combined four datasets analysis NONMEM v7.4.3. Clavulanic was simulated using percentage of time above (%fT > C
Discriminating noninfected from infected neonatal cases remains challenging, and subsequently many neonates are treated with antibiotics in the first week of life. We aimed to study additional value a targeted polymerase chain reaction (PCR) for group B streptococcus (GBS)