A5044376293- Aquaculture disease management and microbiota
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Genomics and Phylogenetic Studies
- Healthcare and Venom Research
- Phytochemistry and Bioactivity Studies
- Immune cells in cancer
- RNA modifications and cancer
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Molecular Sensors and Ion Detection
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Environmental Toxicology and Ecotoxicology
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Meat and Animal Product Quality
- Meningioma and schwannoma management
- Virus-based gene therapy research
- Single-cell and spatial transcriptomics
- Catalytic C–H Functionalization Methods
Xiangya Hospital Central South University
2013-2025
Central South University
2013-2025
University of Oklahoma Health Sciences Center
2023-2025
Zunyi Normal College
2019-2024
Kunming Medical University
2024
Southwest Medical University
2023
First Hospital of Shijiazhuang
2023
Weatherford College
2022-2023
Hebei North University
2021-2022
Anhui Agricultural University
2020
Concentrations of Cu, Zn, Fe, Mn, Pb, Cd, As, and Hg were analyzed in the surface water muscle seven fish species (Carassius auratus, Cyprinus carpio, Hemiculter leucisculus, Pelteobagrus fulvidraco, Silurus meriaionalis, Ctenopharyngodon idellus, Parabramis pekinensis) from Wujiangdu reservoir, China. All metal concen-trations lower than grade one quality values. Mean concentrations decreased order: Zn (10.765 mg kg−1) > Fe (8.908 Mn (0.373 Cu (0.369 Pb (0.158 As (0.102 (0.042 Cd (0.024...
CD47 performs a vital function in cancer therapy by binding to different SIRPα, thrombospondin 1, and integrin. However, its role tumor immunity correlation with prognosis among many types remain unknown. The raw mRNA expression data of patients was downloaded from TCGA GTEx datasets. protein detected using microarray. Kaplan Meier analysis forest plot were performed compare the effects high low on overall survival cancers. In addition, correlations between immune cell infiltration, stromal...
Abstract Introduction Glioma stem cells (GSCs) play an important role in glioma recurrence and chemo‐radiotherapy (CRT) resistance. Currently, there is a lack of efficient treatment approaches targeting GSCs. This study aimed to explore the potential personalized patients with GSC‐enriched gliomas. Methods Single‐cell RNA sequencing (scRNA‐seq) was used identify GSC‐related genes. Then, machine learning methods were applied for clustering validation. The least absolute shrinkage selection...
Growth hormone-secreting pituitary adenoma (GHPA), a benign endocrine tumor located in the base of skull, results acromegaly. In addition to mass effect itself sellar region, GHPA can lead overgrowth almost every organ. Previous findings indicated that processes underlying acromegaly were partly attributable hyperactivity growth hormone/insulin-like factor-1 (GH/IGF-1) axis. However, mechanisms driving this syndrome remains largely unknown. Additionally, roles GHPA-derived exosomes, which...
Glioma is the most lethal primary brain tumor with a poor prognosis and high recurrence rate. Enormous efforts have been made to find therapeutic targets for gliomas. In current study, we identified m5C-related lncRNAs through Pearson correlation analysis by criteria |R|>0.5 p<0.001 in TCGA LGG CGGA325 datasets. We then established an eight-lncRNA prognostic signature (m5C LPS) lasso cox regression multivariate analysis. The performance of was confirmed dataset evaluated differential...
Angiogenesis is more prominent in anaplastic gliomas and glioblastoma (GBM) than that pilocytic diffuse gliomas. Caldesmon (CALD1) plays roles cell adhesion, cytoskeletal organization, vascularization. However, limited information available on mechanisms underlying the effect of CALD1 microvascular facilitation architecture glioma. In this study, we explored role by integrating bulk RNA-seq analysis single analysis. A positive correlation between expression gliomas’ pathological grade was...
Liver cancer is one of the most aggressive tumors and common malignant which seriously threatens human health. Traditional Chinese medicine (TCM) was reported to resist proliferation metastasis liver cells. In this study, we aimed explore potential anti-cancer effect Polygonatum sibiricum polysaccharide (PSP) on tumor immune microenvironment in HepG2 Hep3B cells were pretreated absence or presence PSP (20, 50, 100 µg/mL) for a period 24 h. Subsequently, dendritic (DCs) co-cultured with cell...
Glioblastoma (GBM) is the most aggressive form of brain cancer, with limited therapeutic options. While microglia contribute to GBM progression, mechanisms by which they foster a protumorigenic immune environment remain poorly understood. We identify zinc transporter Zrt- And Irt-Like Protein 4 (ZIP4) as pivotal regulator landscape. In orthotopic mouse models, ZIP4 drives tumor growth and behavioral changes. Mechanistically, modulates microglial plasticity through tumor-derived extracellular...
The objective of this study was to confirm the biological role p38γ in human gliomas. expression profiles and hTERT glioma samples were detected by Western Blot immunohistochemistry. RNA interference performed U251 cells silencing. Cell proliferation apoptosis assayed CCK-8 flow cytometric analysis, then protein levels measured real-time RT-PCR Blot, respectively. Telomerase activity assays Caspase-3,-9 activation also conducted. results showed had a positive correlation with glioma's...
Abstract Oncolytic virus is an attractive anticancer agent that selectively lyses cancer through targeting cells rather than normal cells. Although M1 effective against several types, certain present low sensitivity to it. Here we identified most of the components in cholesterol biosynthesis pathway are downregulated after infection. Further functional studies illustrate mevalonate/protein farnesylation/ras homolog family member Q ( RHOQ ) axis inhibits replication. transcriptome analysis...
Systematic evaluation of the efficacy and safety unilateral biportal endoscopic decompression in treatment lumbar spinal stenosis.We conducted a systematic literature search compared randomized controlled trials (RCTs) retrospective studies endoscopy (UBE) microscopic (MD) stenosis from several databases.Seven were included. The results meta-analysis showed that operation time UBE was shorter than MD. [SMD = -0.443, 95% CI (-0.717, -0.169), P .002]. Compared with MD, patients' back pain...
Pre-slaughter transport stress could induce multiple comprehensive variations in physiological and metabolic parameters of broilers. However, the entire metabolomics pre-slaughter supplementation exogenous energy regulatory substances on broilers is still poorly understood. The metabolome characteristics subjected to 3 h combined with 1,200 mg/kg guanidinoacetic acid (GAA1,200) were analyzed using gas chromatography-mass spectrometry (GC-MS) this study. results showed that, compared control...
Crisp grass carp is a type of (Ctenopharyngodon idella) that has been fed faba beans. Flesh quality and expression muscle quality-related genes in were evaluated. Compared with ordinary carp, 1901 differentially expressed (DEGs) up-regulated 1628 DEGs down-regulated crisp carp. The GO analysis results showed the enriched ribosomes proteins. Kyoto Encyclopaedia genomes (KEGG) pathway amino acid metabolism was closely related to meat quality. COX3, ACADS, ACAT1, ECHS1, EHHADH, HADHAA, HADH,...
Oncolytic virotherapy is a novel and intriguing treatment strategy for cancer therapy. However, the clinical potential of oncolytic virus as single agent limited. M1 promising that has been tested in preclinical studies. In this study, we investigated effect combination use Bcl-2 family inhibitors. A chemical compounds screening including ten inhibitors demonstrated pan-Bcl-2 selectively augmented oncolysis cells at very low doses. The mechanism enhanced antitumor with mainly due to...
An efficient method for the synthesis of highly functionalized products containing cyanide-substituted quaternary carbon centers via DMAP-promoted multicomponent reactions cyanoacetylene, Morita–Baylis–Hillman (MBH) carbonate and water was developed. The could be achieved under simple mild conditions.
To evaluate the long-term outcomes and safety of endoscopic transsphenoidal surgery (ETS) in recurrent residual pituitary adenomas (rrPAs), as well predictors gross total resection (GTR) intraoperative CSF leakage. Furthermore, to compare complications with non-rrPAs cohort.Clinical radiological characteristics patients rrPAs who underwent ETS were collected between 2017 2020. Data from 2019 Logistic regression analyses performed investigate factors influencing Between-group comparisons...