A5103024369- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- DNA Repair Mechanisms
- Head and Neck Cancer Studies
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Cancer Research and Treatments
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
Northwest A&F University
2025
Zhejiang University
2015-2024
Sir Run Run Shaw Hospital
2015-2024
Shenyang The Fourth Hospital of People
2023-2024
Harbin Medical University
2024
Henan Agricultural University
2022-2023
University of California, Los Angeles
2023
National Engineering Research Center for Wheat
2023
Université Paris Cité
2022
Interfaces Traitements Organisation et Dynamique des Systèmes
2022
Abstract Purpose: To evaluate multiparametric MRI features in predicting pathologic response after preoperative chemoradiation therapy (CRT) for locally advanced rectal cancer (LARC). Experimental Design: Forty-eight consecutive patients (January 2012–November 2014) receiving neoadjuvant CRT were enrolled. All underwent anatomical T1/T2, diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE) before CRT. A total of 103 imaging features, analyzed using both volume-averaged voxelized...
BackgroundCBCSG006 trial reported the superior efficacy of cisplatin plus gemcitabine (GP) regimen than paclitaxel (GT) as first-line treatment metastatic triple-negative breast cancer (mTNBC). This study focused on updated survival data and explorations potential biomarkers for efficacy.Patients methodsGerm-line mutations homologous recombination (HR) panel, BRCA1/2 included, were evaluated in 55.9% (132/236) patients. PD-L1 expression was 48.3% (114/236) A nonparametric sliding-window...
LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance triple-negative breast cancer (TNBC). However, the expression and function of LINP1 cervical not yet well-understood. In this study, we evaluated levels tumor tissues cell lines cancer. We found that associates with NHEJ proteins (Ku80 DNA-PKcs). translocates from cytosol to nucleus response irradiation. addition, knockdown significantly increases cleaved caspase3 PARP, leading...
Background/Aims: Bile duct cancer, although not among the most common tumors, still accounts for more and worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues cells explore underlying molecular mechanism regulated by miR-122-5p, this study was designed provide a potential target bile cancer treatment. Methods: Western blot immunohistochemistry were performed detect protein level carcinoma tissues. The transfection efficiency confirmed...
Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of 15%–30% for locally advanced rectal cancer (LARC). This study ventures to shift this paradigm by incorporating short-course nCRT with immunotherapy, specifically Envafolimab, achieve improved treatment efficacy and possibly redefine the standard care LARC. Materials methods: The PRECAM is prospective, single-arm, phase 2 clinical trial LARC in patients microsatellite stable (MSS)...
Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we found an contribution the aberrant activation of wnt in human gastric cancer. CXXC4 (CXXC finger protein 4) was identified as a novel target EZH2 (enhancer zeste homolog 2), and promotes by downregulating expression. inhibits growth cells both vitro vivo through inactivating signaling. contrast, depletion activates anchorage-independent nontumor...
Background and purposeThis study aimed to determine the prognostic factors generate an atlas of a distribution locoregional recurrence (LRR) in patients with distal cholangiocarcinoma (DCCA), after pancreatoduodenectomy (PD) without adjuvant radiotherapy.Materials methods124 DCCA cases registered our institutional database from 2006 2018 were analyzed retrospectively. The Cox proportional hazards model was used for multivariable analysis. All sites centrally reviewed, LRRs plotted on one CT...
(1) Background: An increasing amount of research has supported the role radiomics for predicting pathological complete response (pCR) to neoadjuvant chemoradiation treatment (nCRT) in order provide better management locally advanced rectal cancer (LARC) patients. However, lack validation from prospective trials hindered clinical adoption such studies. The purpose this study is validate a model pCR assessment trial informative insight into validation. (2) Methods: This involved retrospective...
In this study, we aim to compare the progression-free survival (PFS) rates and side effects of induction chemotherapy based on docetaxel, cisplatin fluorouracil (TPF) versus (PF) in patients with locoregionally-advanced nasopharyngeal carcinoma who received subsequent chemoradiotherapy. We randomly assigned 278 stage III or IV NPC (without distant metastases) receive either TPF PF chemotherapy, followed by cisplatin-based chemoradiotherapy every 3 weeks intensity-modulated radiation therapy...
Radiotherapy stands as a cornerstone in the treatment of numerous malignant tumors, including non-small cell lung cancer. However, critical challenge amplifying tumoricidal effectiveness radiotherapy while minimizing collateral damage to healthy tissues remains an area significant research interest. Radiosensitizers, by methods such DNA and fostering creation free radicals, play pivotal role enhancing destructive impact on tumors. Over recent decades, nano-dimensional radiosensitizers have...
TPS2674 Background: Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL-ACT) has demonstrated great therapeutic potential in numerous solid tumors and become an effective treatment for melanoma. However, high-dose lymphodepletion chemotherapy IL-2 infusion during the could cause serious safety risks, even death. The purpose of this study is to develop a TIL product (HS-IT101) that requires low-dose reduce risks improve clinical accessibility. Currently, Phase I trial (NCT06342336)...
FDG-PET in the gallbladder cancer.
The purpose of this study was to evaluate the value vascular endothelial growth factor-A (VEGF-A) expression and other confirmed prognostic factors in predicting clinical outcomes after resection gallbladder carcinoma (GBC). Between January 1999 2006, a total 84 consecutive non-selected patients who underwent for GBC were retrospectively reviewed. Of studied, 45 cases (53.6%) exhibited high VEGF-A placed into group. 14 (16.7%) that showed no VEGF 25 (29.7%) had lower levels pooled low group...
Shading artifacts in CT images are caused by scatter contamination, beam-hardening effect and other non-ideal imaging conditions. The purpose of this study is to propose a novel general correction framework eliminate low-frequency shading (e.g. cone-beam CT, low-kVp CT) without relying on prior information. method based the knowledge relatively uniform number distribution one tissue component. image first segmented construct template where each structure filled with same specific type. Then,...
DUAL-energy computed tomography (DECT) differentiates materials by exploiting the varying material linear attenuation coefficients (LACs) for different x-ray energy spectra. Multi-material decomposition (MMD) is a particularly attractive DECT clinical application to distinguish complicated components within human body. One prior assisted (PMA) image domain MMD method was implemented, but has suffered from inaccurate decomposition, magnified noise, and expensive computation. To suppress we...
134 Background: Chemoradiation is the standard neoadjuvant treatment for locally advanced rectal cancer. Microsatellite stable (MSS)/ mismatch repair proficient (pMMR) cancer rarely responds to immune checkpoint inhibitor monotherapy, but combination with chemoradiation may improve sensitivity of MSS/pMMR tumors by inducing immune-stimulatory effects. Therefore, we aimed investigate efficacy and safety patients treated preoperative short-course radiation followed envafolimab plus CAPEOX...
Abstract Either metastatic or primary squamous cell carcinoma in the gastrointestinal tract is extremely rare, with very few cases reported literature. In this paper, we report a case which patient presented dysphagia during course of radiotherapy for recurrent lung cancer mediastinal lymph node. Although mimicked radiation esophagitis, ultimate cause proved to be gastric and duodenal metastases from carcinoma. Taking into account value identification SCC stomach duodenum on prognosis...