Chronic exposure to ultraviolet B (UVB) is a major cause of skin aging. The aim the present study was determine photoprotective effect 30% ethanol extract

Repetitive exposure to ultraviolet B (UVB) is one of the main causes skin photoaging. We previously reported that dieckol isolated from Eisenia bicyclis extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed evaluate activity a hairless mouse model. In this study, mice were exposed UVB for eight weeks. At same time, at two doses (5 or 10 mg/kg) was administered orally three times week. found suppressed UVB-induced collagen degradation and matrix...

So Shiho Tang (SSHT) is a traditional herbal medicine commonly used in Asian countries. This study evaluated the anti-inflammatory effect of SSHT and associated mechanism using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages murine dextran sodium sulfate (DSS)-induced ulcerative colitis models. Pre-treatment with significantly reduced LPS-induced inflammation by decreasing nitrite production regulating mitogen-activated protein kinase pathway. Meanwhile, mice, DSS-induced symptoms,...

Background/Objectives: Obesity is a major health concern that can lead to various chronic diseases. Little known about the anti-obesity effect of standardized hot water extract from stems Ipomoea batatas (WIB). This study aimed evaluate therapeutic potential WIB as natural alternative conventional treatments by assessing its effects on body weight, fat accumulation, and key metabolic biomarkers in high-fat diet-induced obesity model. Methods: A diet (HFD) induced C57BL/6 mice. The mice were...

Persea americana Mill, cv. Hass, also known as avocado, has been reported to possess hypolipidemic, anti-diabetic, anti-oxidant, cardioprotective, and photoprotective potencies. However, few studies have its anti-colitic effects. In this study, we investigated effects of ethanol extract P. (EEP) in dextran sulfate sodium (DSS)-induced colitic mice the involved molecular mechanisms. EEP effectively improved clinical signs histological characteristics DSS-induced colitis mice. DSS-exposed...

Mass spectrometry-based molecular imaging has been utilized to map the spatial distribution of target metabolites in various matrixes. Among diverse mass spectrometry techniques, matrix-assisted laser desorption/ionization-mass (MALDI-MS) is most popular for due its powerful resolution. This unparalleled high resolution, however, can paradoxically act as a bottleneck when bio-imaging large areas, such whole plant, required. To address this issue and provide more versatile tool scale...

The hepatic adiponectin and farnesoid X receptor (FXR) signaling pathways play multiple roles in modulating lipid glucose metabolism, reducing inflammation fibrosis, altering various metabolic targets for the management of non-alcoholic fatty liver disease (NAFLD). Alisma orientale (AO, Ze xie Chinese Taeksa Korean) is an herbal plant whose tubers are enriched with triterpenoids, which have been reported to exhibit bioactive properties associated NAFLD. Here, present study provides a...

This study introduces an advanced analytical method for quality control of botanical drugs, focusing on Hwang-ryeon-hae-dok-tang (HRHDT), a traditional herbal prescription utilized inflammation, gastritis, fever, and hypertension. Botanical drugs pose challenge due to their complex composition, requiring reliable robust techniques. Our step-by-step procedure included defining the target profile, risk assessment, screening optimizing design experiment, measuring space, Monte Carlo simulation....

Angelicae Dahuricae Radix (ADR) holds a prominent place in traditional medicine for its remarkable antioxidative, anti-allergic, and antiproliferative capabilities. Recognized within the Korean Pharmacopoeia (KP 12th), Angelica dahurica (Hoffm.) Benth. Hook.f. ex Franch. Sav. (AD) var. formosana (H. Boissieu) Yen (ADF) serve as botanical origins ADR. Differentiating these two varieties is crucial formulation quality control of drugs, they are categorized under same medicinal label. This...

The flower buds of Daphne genkwa have been reported as a potent resource associated with anti-angiogenic, anti-tumor, anti-rheumatoid arthritis activities, well immunoregulation. This paper aimed to establish an optimal extraction method for flavonoids, active phytochemicals, and conduct comparative analysis by profiling the different blooming stages. Optimized shaking conditions from design experiments (DoE), such minutely mixture design, 23 full factorial polynomial regression analysis,...

Abstract The present study introduces a systematic approach using analytical quality by design (AQbD) methodology for the development of qualified liquid chromatographic method, which is challenge in herbal medicinal products due to intrinsic complex components botanical sources. ultra-high-performance chromatography-photodiode array-mass spectrometry (UHPLC-PDA-MS) technique 11 flavonoids Genkwa Flos was utilized through entire processes, from risk assessment factor screening test, and...

Various problems worldwide are caused by illegal production and distribution of timber, such as deception about timber species origin logging. Numerous studies on wood tracking being conducted around the world to demonstrate legitimacy timber. Tree identification is most basic element research because quality varies greatly from consistent with botanical commercially distributed wood. Although many recent have combined machine learning-based classification methods various analytical identify...

Medicinal plants have been used as alternative therapeutic tools to alleviate inflammatory diseases. The objective of this study was evaluate anti-inflammatory properties Kyungheechunggan-tang- (KCT-) 01, KCT-02, and Injinchunggan-tang (IJCGT) newly developed decoctions containing 3–11 herbs in LPS-induced macrophages. KCT-01 showed the most potent inhibitory effects on NO, PGE 2 , TNF- α IL-6 production among those three herbal formulas. In addition, significantly inhibited iNOS COX-2 at...

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity various parameters be considered and co-existing multi-components. As case study, reliable HPLC method for simultaneous paeoniflorin from Paeoniae Radix decursin Angelicae Gigantis commercial was developed based on analytical quality design (AQbD) strategy. first step, risk assessment performed select critical (CMPs)...

In this study, we have successfully established a high-performance thin-layer chromatography (HPTLC) method for the quality assessment of Actinidiae Fructus Vermicultus, known as Mokcheonryo(ja) in Korea. This is dried vermiculate fruit Actinidia polygama and A. kolomikta, stipulated by Korean Herbal Pharmacopoeia (KHP). However, herbal market often witnesses inclusion distribution ‘Mihudo’, an alternative product sourced from fruits arguta, belonging to same botanical genus. confluence has...

Real-world intelligent services employing deep learning technology typically take a two-tier system architecture -- dumb front-end device and smart back-end cloud servers. The simply forwards human query while the servers run complex model to resolve respond device. While simple effective, current not only increases load at but also runs risk of harming user privacy. In this paper, we present knowledge caching, which exploits as cache generalized model. locally resolves subset popular or...

Abstract The present study introduces a systematic approach using analytical quality by design (AQbD) methodology for the development of qualified liquid chromatographic method, which is challenge in herbal medicinal products due to intrinsic complex components botanical sources. ultra-high-performance chromatography-photodiode array-mass spectrometry (UHPLC-PDA-MS) technique eleven flavonoids Genkwa Flos was utilized through entire processes, from risk assessment factor screening test, and...

With the rapid development of deep learning, many learning based smart services have emerged. These usually consist two components, frontend user device and back-end cloud server. The front-end only collects queries from sends them to server, all operations are computed in This design has drawbacks increasing load on server violating personal privacy. Knowledge caching is proposed our prior work mitigate these issues, which processes inference for frequently used users devices. In this...