A5063286674- Hemostasis and retained surgical items
- Surgical Sutures and Adhesives
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hydrogels: synthesis, properties, applications
- Fibroblast Growth Factor Research
- Pancreatitis Pathology and Treatment
Southern University of Science and Technology
2022-2025
Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids,...
Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high...
Effective control of post-extraction hemorrhage and alveolar bone resorption is critical for successful extraction socket treatment, which remains an unmet clinical challenge. Herein, injectable Tetra-PEG hydrogel that possesses rapid gelation, firm tissue adhesion, high mechanical strength, suitable degradability, excellent biocompatibility developed as a sutureless coagulation-independent bioadhesive the management sockets. Our results demonstrate robust adhesive sealing by can provide...
Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous...
The development of injectable hydrogels with good biocompatibility, self-healing, and superior hemostatic properties is highly desirable in emergency clinical applications. Herein, we report an situ self-healing hydrogel based on choline phosphoryl functionalized chitosan (CS-g-CP) oxidized dextran (ODex). CP groups were hypothesized to accelerate hemostasis by facilitating erythrocyte adhesion aggregation. Our results reveal that the CS-g-CP/ODex exhibit enhanced blood clotting...
Developing biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) N-hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked rapidly forms after UV light irradiation covalently bonds to the underlying provide robust adhesion....