A solution to the unmet synthetic challenge of achieving highly atropo-enantioselective transesterification Bringmann's lactones has been realized, employing a chiral bifunctional amine thiourea as promoter. The synergistic activation and alcohols/phenols by respective groups is crucial for enantioselective, high-yielding dynamic kinetic resolution process. This protocol gives optically pure, axially biaryl compounds with broad substrate scope under mild reaction conditions.

Abstract A simple formylation reaction of aryl halides, triflates, and vinyl bromides under synergistic nickel‐ organic‐dye‐mediated photoredox catalysis is reported. Distinct from widely used palladium‐catalyzed processes, this proceeds by a two‐step mechanistic sequence involving initial in situ generation the diethoxymethyl radical diethoxyacetic acid 4CzIPN‐mediated reaction. The formyl‐radical equivalent then undergoes nickel‐catalyzed substitution reactions with halides triflates to...

We describe a synergistic catalysis strategy for the asymmetric direct addition of simple aldehydes to 4-vinylpyridines. By means independent activation weakly electrophilic 4-vinylpyridines by Brønsted acid CF3SO3H (TfOH) and chiral diphenylprolinol tert-butyldimethylsilyl (TBDMS) ether-catalyzed formation nucleophilic enamines in cooperative manner, previously unattainable highly enantioselective process has been realized first time. Notably, power is fueled its high efficiency production...

Nitro-charged activation: An organocatalytic enantioselective conjugate addition of aryl methyl nucleophiles to enals has been developed produce ubiquitous chiral benzylic building blocks (see scheme; TES=triethylsilyl). Taking advantage the strongly electron-withdrawing nature nitro groups, which can be conveniently transformed into other functionalities, this functionality was incorporated aromatic systems as a temporary activating group.

Abstract Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity engineered into α‐amino‐acid‐forming Petasis reaction occurring between aryl acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity process its ability generate structurally diverse valued aryl, heteroaryl, α,β‐unsaturated aldehydes containing wide array functional groups, demonstrates practical utility new synthetic strategy.

An enantioselective Michael addition of ketones to alkylidenemalononitriles catalyzed by chiral primary amine I with (R)-5c as a co-catalyst in good yields (>90%) and enantioselectivities (85-96% ee) has been developed. The strategy also extended three-component version through domino Knoevenagel/Michael sequence similar or better outcomes.

A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion simple azaarenes α,β-unsaturated aldehydes. preparative power demonstrated in anxiolytic drug saripidem two one-pot operations with overall 45% yield.

Synergistic dual cyclizations and quenching mechanisms of acrylate maleimide groups for improved turn-on fluorescence detection cysteine.

An organocatalytic highly enantioselective Michael–aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated produce reactive nulecophilic species in process under mild conditions.

A metal-free catalytic approach to tryptanthrins has been achieved for the first time. The unique process is realized by an organocatalytic and indole anthranilic acid substrate co-catalyzed photochemical oxidative condensation with visible light O2. truly environmentally friendly reaction conditions enable various reactants participate in deliver structurally diverse tryptanthrins.

Abstract A simple formylation reaction of aryl halides, triflates, and vinyl bromides under synergistic nickel‐ organic‐dye‐mediated photoredox catalysis is reported. Distinct from widely used palladium‐catalyzed processes, this proceeds by a two‐step mechanistic sequence involving initial in situ generation the diethoxymethyl radical diethoxyacetic acid 4CzIPN‐mediated reaction. The formyl‐radical equivalent then undergoes nickel‐catalyzed substitution reactions with halides triflates to...

An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads synthetically interesting densely functionalized 3,3′-disubstituted oxindoles with creation up three stereogenic centers.

Direct formylation of feedstock indoles with newly developed, cost-effective deuterated glyoxylic acid as agent under visible light and air (O2) terminal oxidant has been developed. An isatin byproduct produced from the corresponding indole reactant serves a facilitator for process. The simple, mild, metal- oxidant-free protocol enables synthesis structurally diverse C1-deuterated 3-formylindoles broad functional group tolerance late-stage functionalization at high level D-incorporation (95–99%).

The broad synthetic utility of labile enol esters demands efficient methods for the stereo- and regioselective synthesis both Z E isomers. available dominated by metal catalysis cannot meet challenge. We wish to report a metal-free organocatalytic divergent approach isomers from same reactant pools with catalytic system. A process involves an amine-catalyzed conjugate addition carboxylic acids ynals, which triggers rearrangement leading esters. reaction proceeds highly regio-...

The Chinese Altai in northwestern Xinjiang has numerous outcrops of granitoids which provide critical information on accretionary orogenic processes and crustal growth the Central Asian Orogenic Belt. Zircon U–Pb ages, Hf-isotopic compositions whole-rock geochemistry monzogranite granodiorites Qinghe County are employed to elucidate Paleozoic tectonics Altai. Granodiorites have crystallization ages 424.6 ± 3.1 Ma (MSWD = 0.23) 404.0 3.4 0.18); was emplaced early Permian with a age 293.7 4.6...

Abstract In this study, we report the harnessing of new reactivity N , O ‐acetals in an aminocatalytic fashion for organic synthesis. Unlike widely used strategies requiring use acids and/or elevated temperatures, direct replacement amine component by carbon‐centered nucleophiles C−C bond formation is realized under mild reaction conditions. Furthermore, without necessary preformation ‐acetals, amine‐catalyzed situ developed. Coupling both reactions into a one‐pot operation enables...

Discriminative correlation filter (DCF)-based methods have demonstrated superior performance in UAV tracking via fusing multiple types of features and updating models online. However, most DCF-based trackers simply cascade different features, failing to fully take advantage their complementary strength. In addition, online update strategies are limited using a single fixed learning rate, which often leads model degradation when suffering challenges. this paper, we present an Auto-Perceiving...