Cunninghamella spp. is a group of fungi belonging to the Mucorales order. Cases fungal endocarditis are sporadic, but more frequent in immunocompromised patients. COVID-19 (SARS-CoV-2 Infection Disease 2019) infections, prematurity, deferoxamine treatment, iron overload, neutropenia, diabetes, and malignant hemopathies proved be risk factors for mucormycosis. We present case 7-year-old boy who was treated every three weeks with blood transfusion major beta-thalassemia, receiving secondary...

Down syndrome is the most common chromosomal abnormality diagnosed in newborn babies. Infants with have characteristic dysmorphic features and can neuropsychiatric disorders, cardiovascular diseases, gastrointestinal abnormalities, eye problems, hearing loss, endocrine hematologic many other health issues. We present case of a syndrome. The infant was female, born at term through c-section. She before birth complex congenital malformation. In first few days life, stable. her 10th day she...

One of the main markers arterial stiffness is pulse wave velocity (PWV). This parameter well studied as a marker for end-organ damage in adult population, being considered strong predictor major cardiovascular events. study assessed PWV children with chronic kidney disease (CKD) risk. We conducted prospective observational single-center cohort 42 consecutively pediatric patients (9-18 years old) terminal CKD and dialysis, at Hemodialysis Department "M. S. Curie" Hospital, Bucharest. measured...

Acute myocardial infarction (AMI) in children is rather anecdotic. However, following COVID-19, some conditions may develop which favor thrombosis, infarction, and death. Such a condition Kawasaki-like disease (K-lD). K-lD appears as subgroup of the multisystem inflammatory syndrome (MIS-C). In cases, patients giant coronary aneurysms. The evolution characteristics aneurysms from appear to be different classical Kawasaki (KD) Differences include lower percentage aneurysm formation than...

Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a novel discovered in 2019 that caused the disease (COVID19). During last year, over 70 million people were infected and more than 1.5 died. Despite tremendous number of infected, children less affected presented milder forms disease. A short time after pandemic was declared, new hyperinflammatory syndrome resembling Kawasaki (KD) described with confirmed or suspected SARS-CoV-2 infection named multisystem inflammatory (MIS-C). The...

Anomalous origin of the right coronary artery (RCA) from pulmonary artery, ARCAPA, is an extremely rare congenital heart disease. Only 200 cases were reported 1885 to present. Patients diagnosed with ARCAPA can be either asymptomatic or experience symptoms, such as murmur, dyspnea, angina, shortly after birth around 40-60 years life. Usually, those isolated are later in life compared who associate other structural cardiac defects. We report two anomalous at level trunk (ARCAPA) that by...

Abstract Cardiac emergencies in children represent an extremely important issue medical practice. In general, interventional treatment could be optional many situations, however it can indicated emergency conditions. There are diseases at pediatric age that benefit from treatment, thus reducing the surgical risks and subsequent complications. Balloon atrioseptostomy, patent ductus arteriosus (PDA) closure, percutaneous or hybrid closure of a ventricular septal defect, pulmonary aortic...

Abstract Closure of the atrial septal defect (ASD) and patent ductus arteriosus (PDA) are among most frequent cardiac interventional procedures. This was a prospective study, which started together with implementation national program pediatric cardiology in Romania. We used Cocoon devices 83 consecutive cases from 92 implantations for ASD PDA. 27 were closure 56 PDA closure. Regarding closure, median age 8.5 years (range 3–25 years) weight 25 kg 11.5–63 kg). The mean follow-up 17.4 ± 6.7...

Contrast agents are among the most frequently used drugs in medical practice. The aim of our study was to evaluate incidence complications associated with use different contrast an angiography lab dedicated pediatric patients congenital heart disease. Between June 2015 and December 2017, 166 disease were diagnosed and/or treated lab. Of these patients, 38 excluded because they did not require substance administration. As interventional procedures we performed pulmonary valvular dilatation 17...

<h3>Aim</h3> A giant aneurysm of the right atrial appendage (ARAA) a rare cardiac anomaly unknown cause characterized histopathologically by focal thinning endocardium, myocardium, and to disappearance pectinate muscles. Between 1955 1998, 60 cases were reported worldwide, later sporadic cases, which less than 20 in children. In most is asymptomatic, but it can increase size associating palpitations, dyspnea, thrombosis with embolic manifestations, supraventricular arrhythmias up compression...

Isolated right ventricle hypoplasia (IRVH) is a disease characterized by an underdeveloped ventricle. It congenital heart than can associate heterogeneous structural defects and nonspecific clinical features, which often present challenging therapeutic management. In this article, there are presented diagnostic methods treatment options for (RVH) according to patients age associated defects. RVH has different prognosis in accordance with the severity of patient's at diagnosis established....

Abstract Pediatric multisystem inflammatory syndrome (PMIS) appears to be a relatively rare complication of COVID-19 in children, occurring less than 1% children with confirmed SARS-CoV-2 infection. This condition can appear several weeks after the acute infection and is assumed delayed immune response coronavirus disease 2019 which lead severe cardiovascular involvement. In this retrospective study, our main purpose was summarize clinical data from three types onsets patients diagnosed PMIS...

Abstract Kawasaki disease is a challenging diagnosis even in typical forms of presentation. The features are represented by long lasting fever, specific mucocutaneous signs and coronary artery dilations as expression medium vasculitis unknown origin. Kawasaki-like emerged variant pediatric multisystem inflammatory syndrome (PMIS) associated with COVID-19 infection. A 1 year 9-month-old boy who presented semi-consistent stools, vomiting, facial edema hepatomegaly was transferred our hospital...

Paracetamol (N-acetyl- para-aminophenol) also known as acetaminophen is a chemical compound used in medical practice for analgesic and antipyretic effects. The mechanism of action related to the cyclooxygenase (COX) activity, which not full inhibit nonsteroidal anti-inflammatory. selectively inhibits COX activities brain, indirectly by reducing COX, must be oxidized order function. In addition effects, modulating prostaglandin synthesis selective inhibition vascular modulator effect was...