A5017936206- Phytoestrogen effects and research
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds and Antitumor Agents
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Cancer Risks and Factors
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Natural product bioactivities and synthesis
- DNA Repair Mechanisms
- Nanoparticle-Based Drug Delivery
- Garlic and Onion Studies
- Tea Polyphenols and Effects
- Cancer Immunotherapy and Biomarkers
- Synthesis and biological activity
- Lung Cancer Research Studies
- Food Quality and Safety Studies
- RNA Interference and Gene Delivery
- Gene Regulatory Network Analysis
- Cancer, Lipids, and Metabolism
University of Cyprus
2013-2024
Fundación Ciencias Exactas y Naturales
2020-2023
University of Buenos Aires
2016-2023
Centro Científico Tecnológico - San Juan
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2020
University of Nicosia
2020
University of Leeds
2009
University of Ioannina
2007
University of Illinois Chicago
1996-2005
University of Illinois Urbana-Champaign
1995-2004
Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested estrogenic activity. Methanol extracts red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors α (ERα) β (ERβ). With cultured Ishikawa (endometrial) cells, exhibited activity as indicated by induction alkaline phosphatase (AP) up-regulation progesterone receptor (PR) mRNA. Chasteberry...
Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, morin found both enzymes, while phloretin, kaempferol, 4',6,7-trihydroxyisoflavone inhibited topo II without inhibiting I. Flavonoids demonstrating potent inhibition required hydroxyl group substitution at C-3, C-7, C-3', C-4' positions also a keto C-4. Additional B-ring hydroxylation enhanced flavonoid inhibitory action. A C-2, C-3 double...
Journal Article Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage Get access Rajendra G. Mehta, Mehta 1Specialized Center, College Medicine, University Illinois at ChicagoChicago, IL 60612, USA22Department Medicinal Chemistry and Pharmacognosy, Pharmacy, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Jinfang Liu, Liu 3Department Chemistry, Arts Sciences, Andreas Constantinou, Constantinou Cathy F. Thomas, Thomas Michael Hawthorne,...
Treatment of breast cancer underwent extensive progress in recent years with molecularly targeted therapies.However, non-specific pharmaceutical approaches (chemotherapy) persist, inducing severe side-effects.Phytochemicals provide a promising alternative for prevention and treatment.Specifically, resveratrol (res) is plant-derived polyphenolic phytoalexin potent biological activity but displays poor water solubility, limiting its clinical use.Here we have developed strategy delivering res...
Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to restrain its metastatic potential urgently needed. In this study, we aimed identify novel genes that drive metastasis BLBC elucidate underlying mechanisms action.An unbiased approach using gene expression profiling a progression model in silico leveraging pre-existing tumor transcriptomes...
Abstract Background Soy phytoestrogens, such as daidzein and its metabolite equol, have been proposed to be responsible for the low breast cancer rate in Asian women. Since majority of estrogen receptor positive patients are treated with tamoxifen, basic objective this study is determine whether equol enhances tamoxifen’s anti-tumor effect, identify molecular mechanisms involved. Methods For purpose, we examined individual combined effects tamoxifen on estrogen-dependent MCF-7 cells using...
Background: The form of vitamin D (vitamin 3 ) in fortified milk and the provitamin produced by body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin [1α,25(OH) 2 ]. This compound can induce cell differentiation prevent proliferation cancer cells. However, because 1α,25(OH) is hypercalcemic (effective increasing serum calcium level), it not suitable for use prevention or therapy trials. Purpose: We synthesized 5 series analogue, 1ahydroxy,...
Emerging infectious diseases of wildlife have been recognized as a major threat to global biodiversity. Endemic species on isolated oceanic islands, such the Galápagos, are particularly at risk in face introduced pathogens and disease vectors. The black salt-marsh mosquito (Aedes taeniorhynchus) is only widely distributed across Galápagos Archipelago. Here we show that this naturally colonized before arrival man, since then it has evolved represent distinct evolutionary unit adapted habitats...
Extracts derived from the Ceratonia siliqua L. (carob) tree have been widely studied for their ability to prevent many diseases mainly due presence of polyphenolic compounds. In this study, we explored, first time, anti-cancer properties Cypriot carobs. We produced extracts ripe and unripe whole carobs, pulp seeds using solvents with different polarities. measured inhibit proliferation induce apoptosis in cancer normal immortalized breast cells, MTT assay, cell cycle analysis Western...
Programmed cell death protein ligand‐1 ( PD‐L1 ) expression in non‐small lung cancer (NSCLC) tumors guides treatment selection. circulating tumor cells (CTCs) may provide further information. We have explored and marker of proliferation Ki‐67 Ki67 ; also known as MKI67 CTCs longitudinal samples 47 advanced NSCLC patients receiving pembrolizumab. A triple immunofluorescence, against cytokeratin, PD‐L1, Ki67, was performed on peripheral blood mononuclear cells, at baseline, post‐first cycle,...
The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism action. In effort determine if black cohosh had additional health benefits, methanol extracts were investigated for their potential scavenge reactive oxygen species and protect against menadione-induced DNA damage. These effectively scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. addition, the showed dose-dependent decreases...
There are conflicting reports on the effect of soy and its components mammary carcinogenesis in adult female rats, mainly because different rodent models that used chemoprevention studies. The present study was undertaken to compare tumor-preventative effects protein isolate (SPI) two isoflavones a "standard" model had been for identification many chemopreventive agents. Six groups Sprague-Dawley rats were provided with modified cornstarch AIN-76A diets supplemented as follows: no additional...