A5040997688- Pain Mechanisms and Treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Automotive and Human Injury Biomechanics
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Shoulder Injury and Treatment
- Effects of Vibration on Health
- Neuropeptides and Animal Physiology
- Spinal Cord Injury Research
- Pediatric Pain Management Techniques
- Nerve injury and regeneration
- Cervical and Thoracic Myelopathy
- Osteoarthritis Treatment and Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Elasticity and Material Modeling
- Tendon Structure and Treatment
- Myofascial pain diagnosis and treatment
- Medical Imaging and Analysis
- Bone fractures and treatments
- Temporomandibular Joint Disorders
- Cellular Mechanics and Interactions
- Biomedical and Engineering Education
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Treatment
University of Pennsylvania
2015-2025
Hospital of the University of Pennsylvania
2018-2021
Pennsylvania Hospital
2016-2021
Bioengineering Center
2012-2015
Division of Undergraduate Education
2015
California University of Pennsylvania
2014
Philadelphia University
2012
University of Bern
2011
Duke University
1995-2002
Dartmouth–Hitchcock Medical Center
2001-2002
Abstract The specific mechanisms by which nervous system injury becomes a chronic pain state remain undetermined. Historically, it has been believed that injuries proximal or distal to the dorsal root ganglion (DRG) produce distinct pathologies manifest in different severity of symptoms. This study investigated role site relative DRG (1) eliciting behavioral responses, (2) inducing spinal neuroimmune activation, and (3) responding pharmacologic interventions. Rats received either an L5 nerve...
Cervical facet capsular strains were determined during bending and at failure in the human cadaver.To determine effect of an axial pretorque on estimate risk for subcatastrophic injury normal motions.Epidemiologic clinical studies have identified capsule as a potential site prerotation factor whiplash injury. Unfortunately, biomechanical data cervical its role are not available.Cervical spine motion segments tested pure-moment test frame full-field throughout capsule. Motion with without...
Study Design. A comparison of cervical facet capsule strain fields in cadaveric motion segments exposed to whiplash-like loads and failure loads. Objectives. To compare the maximum principal capsular ligament under combined shear, bending, compressive with those required injure ligament. Summary Background Data. The is thought be an anatomic site for whiplash injury, although mechanism its injury remains unclear. Methods. Motion from seven female donors were quasi-static flexibility tests...
Spinal cord stimulation (SCS) is widely used to treat neuropathic pain. Burst SCS, an alternative mode of stimulation, reduces pain without paresthesia. However, the effects and mechanisms burst SCS have not been compared conventional tonic in controlled investigations. This study compares attenuation spinal neuronal activity tactile allodynia, role γ-aminobutyric acid (GABA) signaling during or a rat model cervical radiculopathy.The were by recording firing before after each at day 7...
This study explores the dynamics of head and cervical spine impact with specific goals determining effects inertia surface on injury risk. Head experiments were performed using unembalmed neck specimens from 22 cadavers. These included impacts onto compliant rigid surfaces oriented to produce both flexion extension attitudes. Tests conducted a drop track system velocities order 3.2 m/s. Injuries occurred 2 30 msec following prior significant motion.These demonstrate that in absence...
Whiplash injury can produce pain in the neck, arm, and hand, has been associated with inflammation. However, relationship between inflammatory responses symptoms remains unknown, hindering development of appropriate therapeutics for whiplash symptoms. Two joint loading paradigms were used separately an established rat model painful cervical facet distraction to apply: (1) gross failure, (2) subfailure capsular ligament. Behavioral outcomes compared determine whether more severe mechanical...
Excessive cervical facet capsular ligament stretch has been implicated as a cause of whiplash-associated disorders following rear-end impacts, but the pathophysiological mechanisms that produce chronic pain in these cases remain unclear. Using rat model C6–C7 joint capsule produces sustained mechanical hyperalgesia, presence neuronal hyperexcitability was characterized 7 days after loading. Extracellular recordings spinal dorsal horn activity between C6 and C8 (117 neurons) were obtained...
ABSTRACT The development of an in vivo rodent discogenic pain model can provide insight into mechanisms for painful disc degeneration. Painful degeneration rodents be inferred by examining responses to external stimuli, observing pain‐related behaviors, and measuring functional performance. This study compared the sensitivity multiple assessment methods disruption identifying parameters sensitive rats. Disc was induced rats annular injury with saline injection. severity degeneration,...
Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor-alpha (TNFα) is commonly associated with low back pain, but the direct relationship remains unclear.Treatment strategies for pain require improved understanding of complex relationships between intradiscal pro-inflammatory cytokines, structural IVD degeneration. A rat in vivo lumbar puncture model was used to 1) determine role TNFα initiating painful...
Although blast-induced traumatic brain injury (bTBI) is well recognized for its significance in the military population, unique mechanisms of primary bTBI remain undefined. Animate models are critical determining these potentially mechanisms, but biomechanical characteristics many poorly understood. In this study, we examine some common shock tube configurations used to study laboratory and define optimal configuration minimize effect torso overpressure head accelerations. Pressure...
Diffuse axonal injury (DAI) is a form of brain that characterized by morphologic changes to axons throughout the and brainstem. Previous biomechanical studies have shown primary dysfunction, ranging from minor electrophysiologic disturbances immediate axotomy, can be related rate level deformation. Some existing rodent head models display varying degrees in forebrain brainstem, but extent damage has been limited contused hemisphere. This study examined whether opening dura mater over...
An in vivo rat model of transient cervical nerve root compression.To investigate the potential for compression to produce behavioral hypersensitivity and examine its dependence on compression.Clinically, injury has been hypothesized as a source neck pain, particularly because roots are at mechanical risk during loading. Lumbar radiculopathy models ligation show that allodynia spinal glial changes depend deformation magnitude. However, no investigation performed cause pain.Two compressive...
Detecting the initiation of mechanical injury to biological tissue, and not just its ultimate failure, is critical a sensitive specific characterization tissue tolerance, development quantitative relationships between macro- microstructural responses, appropriate interpretation physiological responses loading. We have developed novel methodological approach detect onset spatial location structural damage in collagenous soft before visible rupture, via identification atypical regional...