A5063955986- Medication Adherence and Compliance
- Cancer Immunotherapy and Biomarkers
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Pharmaceutical Practices and Patient Outcomes
- Advanced Breast Cancer Therapies
- Atrial Fibrillation Management and Outcomes
- Health Policy Implementation Science
- Colorectal Cancer Treatments and Studies
- Cardiac pacing and defibrillation studies
- Chemotherapy-induced cardiotoxicity and mitigation
- HER2/EGFR in Cancer Research
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Health Sciences Research and Education
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Medicinal Plants and Bioactive Compounds
- Healthcare Systems and Practices
- Lung Cancer Research Studies
- Pharmacy and Medical Practices
- Inflammatory mediators and NSAID effects
University of California, Irvine
2022-2025
Okayama University
2023
Okayama University Hospital
2023
VA Greater Los Angeles Healthcare System
2019-2023
Western University of Health Sciences
2017-2023
Sunnybrook Health Science Centre
2023
Health Sciences Centre
2023
Health Net
2023
University Health Network
2023
Women's College Hospital
2023
A method for polyethylene glycol-induced protoplast transformation of glutamate-producing bacteria with plasmid DNA was established. Protoplasts were prepared from cells grown in the presence penicillin by treatment lysozyme a hypertonic medium. The concentration during growth affected efficiency formation, regeneration, and uptake protoplasts. Regeneration protoplasts accomplished on agar medium containing sodium succinate yeast extract. spectinomycin streptomycin resistance pCG4,...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are cardioprotective agents in patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease (CVD). Since little is known about their uptake CVD, we examined SGLT2 inhibitor prescribing trends identified potential disparities patterns.We conducted an observational study using linked population-based health data Ontario, Canada, from April 2016 to March 2020 of aged 65 years or older concomitant CVD. To examine prevalent...
A new cryptic plasmid, pTA1030 (4.5 megadaltons, copy number 16), was characterized by restriction analysis, together with some other plasmids of Bacillus subtilis.
Health disparity is defined as a type of health difference that closely linked with social, economic and/or environmental disadvantage. Over the past two decades, major efforts have been undertaken to mitigate disparities and promote equity in United States. Within pharmacy practice, also identified play role influencing pharmacists' practice across various clinical settings. However, well-characterized solutions address such disparities, particularly within are lacking literature....
Abstract Although an association has been reported between diuretics and myocarditis, it is unclear whether the risk of immune checkpoint inhibitor (ICI)‐induced myocarditis affected by concomitant diuretics. Thus, aim this work was to evaluate impact on ICI‐induced myocarditis. This cross‐sectional study used disproportionality analysis a pharmacovigilance database assess with various in patients receiving ICIs via data entered into VigiBase through December 2022. Multiple logistic...
Objective: To investigate racial disparities in the first-time prescription of mood stabilizers for first-episode mania nonpsychotic, hospitalized patients with bipolar I disorder, specifically comparing rates lithium and valproic acid between non-Hispanic Black White patients. Methods: A retrospective cohort study was conducted using TriNetX database. We included eligible non Hispanic newly diagnosed disorder without psychotic features January 1, 2014, December 31, 2023. Propensity score...
125 Background: Addition of NHT, including Abiraterone, Enzalutamide, Apalutamide, and Darolutamide, to androgen deprivation therapy in patients with advanced PCa demonstrated improved survival large randomized controlled trials. However, NHTs are associated development metabolic syndrome CV toxicity. Treatment related adverse events (TRAEs) may include hypertension (HTN), hyperglycemia, atrial fibrillation, myocardial infarction (MI), congestive heart failure (CHF), stroke. As such,...
ABSTRACT Introduction Carfilzomib use has been extensively associated with cardiovascular toxicity; the risk ixazomib, a novel oral proteasome inhibitor, is underreported and no large comparative analysis available. Methods We conducted retrospective cohort study utilizing TriNetX platform to compare toxicity outcomes among multiple myeloma patients who received lenalidomide, dexamethasone, ixazomib (IRd) or carfilzomib (KRd). Results After propensity‐score‐matching 478 from each cohort,...
Identifying sources of sex-based disparities is the first step in improving clinical outcomes for female patients. Using All Us data, we examined association biological sex with cost-related medication adherence (CRMA) issues patients cardiovascular comorbidities.
We evaluated the characteristics of a coenzyme Q(10) (CoQ(10)) formulation created with gum arabic. defined formulation's "modulus inclusion," reference index emulsified state, as CoQ(10) not extracted by hexane percentage total content formulation. The had smaller particle size and larger modulus inclusion value than equivalent unemulsified In kinetic study in rats, serum levels were significantly greater formulation, which barely increased levels. human study, oral intake plasma levels,...
<b>Objective.</b> To explore cultural influences on US and Japanese pharmacy students' evidence-based medicine (EBM) attitudes, knowledge, behavior. <b>Methods.</b> A cross-sectional study was conducted using a self-administered survey. Senior students in one school the United States two schools Japan were invited to complete 33-item survey instrument. <b>Results.</b> Students both countries reported having positive attitudes understanding of EBM concepts. In their self-evaluation, American...
Background: Slow uptake of sacubitril/valsartan in patients with heart failure reduced ejection fraction has been reported, which may negatively impact clinical outcomes. We characterized prior authorization (PA) burden, prescription copayment, and utilization by insurance plan type to identify potential barriers its use. Methods: conducted a national population-level, cross-sectional study using PA data from an coverage website accessed March 2019 IQVIA National Prescription Audit August...
A subset of bacteremia cases are caused by organisms not detected a rapid-diagnostics platform, BioFire blood culture identification (BCID), with unknown clinical characteristics and outcomes. Patients ≥1 positive over 15-month period were grouped negative (NB-PC) versus (PB-PC) BCID results compared respect to demographics, infection characteristics, antibiotic therapy, outcomes (length hospital stay [LOS] in-hospital mortality).
Background Despite improved outcomes associated with ticagrelor compared clopidogrel in acute coronary syndrome (ACS), many studies have demonstrated slow adoption of the United States because its increased cost. Less is known about how adopted when there no added cost consideration. Our objectives were to determine patterns use ticagrelor, hospital-level use, and factors after ACS a publicly funded health care system. Methods Results We conducted population-based cohort study including...
Abstract Purpose P2Y12 inhibitors (P2Y12i) reduce cardiac events after acute coronary syndromes (ACS). However, suboptimal P2Y12i adherence persists. We aimed to examine non‐adherence using group‐based trajectory methods and identify predictors. Methods conducted a population‐based, retrospective cohort study administrative data in Ontario, Canada of patients ≥65 years admitted for ACS between April 2014 March 2018 with dispensed within 7 days discharge. used models characterize longitudinal...
The functional role of ATP released from sympathetic nerve terminals was examined in isolated guinea pig ventricular papillary muscles. contractile force muscles increased by field electrical stimulation endings. This increase attenuated pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS) or suramin, blockers the P2X receptor, and abolished propranolol prazosin. PPADS, affected neither basal nor positive inotropic effect noradrenaline. These results provide evidence that enhances...