A5060176990- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Chemical Synthesis and Analysis
- Gastrointestinal Tumor Research and Treatment
- Bone fractures and treatments
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Screening and Detection
- Synthetic Organic Chemistry Methods
- Peptidase Inhibition and Analysis
- Orthopaedic implants and arthroplasty
- Multiple Myeloma Research and Treatments
- Esophageal Cancer Research and Treatment
- Cell Adhesion Molecules Research
- Pancreatitis Pathology and Treatment
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Ubiquitin and proteasome pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 and healthcare impacts
- Carbohydrate Chemistry and Synthesis
- Metastasis and carcinoma case studies
IRCCS Humanitas Research Hospital
2019-2025
Politecnico di Milano
2025
Humanitas University
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2023
Università Campus Bio-Medico
2023
Campus Bio Medico University Hospital
2023
Dutch Colorectal Cancer Group
2023
Collaborative Group (United States)
2023
University of Milan
2005-2022
University of Milano-Bicocca
2011-2021
Italy recorded its first case of confirmed acute respiratory illness because coronavirus on February 18, 2020, soon after the initial reports in China. Since that time, and nations throughout world have adopted very stringent severe measures to protect populations from spread infection. Despite these measures, number infected people is growing exponentially, with a significant patients developing insufficiency. Endoscopy departments face risk for diffusion diseases can be via an airborne...
See editorial on page 36. Up to 20% of health care personnel (HCP) were found be infected with coronavirus disease (COVID-19)1Lancet. 2020; 395: 922Abstract Full Text PDF Scopus (853) Google Scholar in the outbreak northern Italy.2Dipartimento della Protezione Civile.http://www.protezionecivile.gov.it/media-comunicazione/comunicati-stampaGoogle Recommendations patient and HCP protection have been made, such as postponing procedures, triage, use personal protective equipment (PPE), creation...
The purpose was to assess in Italy the clinical features at diagnosis of inflammatory bowel disease (IBD) children.In 1996 an IBD register onset established on a national scale.Up end 2003, 1576 cases pediatric were recorded: 810 (52%) ulcerative colitis (UC), 635 (40%) Crohn's (CD), and 131 (8%) indeterminate (IC). In period 1996-2003 increase incidence from 0.89 1.39/10(5) inhabitants aged <18 years observed. more frequent among children between 6 12 (57%) but 20% patients had under age;...
High-throughput screening highlighted 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile (1) as an active inhibitor of ubiquitin-specific proteases (USPs), a family hydrolytic enzymes involved in the removal ubiquitin from protein substrates. The chemical behavior compound 1 was examined. Moreover, synthesis and vitro evaluation new compounds, analogues 1, led to identification potent selective inhibitors deubiquitinating enzyme USP8.
To assess frequency, types, and mechanisms of comorbidities in people with epilepsy verify their association disease features outcome.This cohort study was performed 13 Italian centers nationwide distribution accurate records. Eligible patients were children adults diagnosed before December 31, 2005, followed for a minimum 10 years. Two pairs raters independently reviewed patients' records classified each comorbidity. In case disagreement, third reviewer made the final decision....
Bortezomib (BTZ) is the first proteasome inhibitor entered in clinical practice. Peripheral neuropathy likely to be a class side effect of these drugs, although its severity largely variable, and it deserves further investigated, since mechanisms BTZ-induced peripheral neurotoxicity (BiPN) are still unknown. In our study, we investigated vivo vitro possible pathogenic events relevant BiPN using well-established rat model, with particular reference extent inhibition effects on α-tubulin...
Nirmatrelvir is a potent, selective, and orally bioavailable inhibitor of SARS-CoV-2 Mpro. Herein, we report scalable cyclopropanation to produce the bicyclic [3.1.0]proline derivative, which one key starting materials for synthesis nirmatrelvir. To ensure robust supply chain this building block meet significant API demand, needed develop synthetic process that was complementary existing strategies. achieve goal, used widely available inexpensive raw material...
Summary Objective The new epilepsy definition adopted by the International League Against Epilepsy ( ILAE ) includes patients with one unprovoked seizure a probability of further seizures, similar to general recurrence risk after two occurring in 10‐year period. Long‐term follow‐up diagnosed single is needed assess applicability clinical practice. Methods Patients newly were recruited retrospectively minimum 10 years. stratified groups depending on occurrence (new definition, ND or more...
Letters15 April 2020Clinician Education and Adoption of Preventive Measures for COVID-19: A Survey a Convenience Sample General Practitioners in Lombardy, ItalyFREEGionata Fiorino, MD, PhD*, Matteo Colombo, MD*, Carmela Natale, BSc, Elena Azzolini, PhD, Michele Lagioia, Silvio Danese, PhDGionata PhD*Humanitas Clinical Research Center IRCCS, Rozzano, Humanitas University, Pieve Emanuele, Milan, Italy (G.F.)Search more papers by this author, MD*Humanitas (M.C.)Search BScHumanitas Center,...
Abstract Background and study aims EUS-guided choledochoduodenostomy (EUS-CDS) is a minimally invasive procedure used to treat malignant biliary obstruction (MBO) by transduodenal placement of lumen-apposing metal stent (LAMS) into the extrahepatic bile duct. To identify factors that contribute safe effective EUS-CDS using LAMS, we performed systematic review literature meta-analysis. Methods The methodology our analysis was based on PRISMA recommendations. Electronic databases (Medline,...