A5010476584- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Photosynthetic Processes and Mechanisms
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Protein Tyrosine Phosphatases
- Cancer Mechanisms and Therapy
- Respiratory and Cough-Related Research
- MicroRNA in disease regulation
Ningbo University
2018-2025
Ningbo Medical Center Lihuili Hospital
2021-2025
Jiangxi University of Finance and Economics
2025
Ningbo First Hospital
2023-2024
Bridge University
2023
Wenzhou Medical University
2022-2023
Ningbo University Affiliated Hospital
2023
Tongji University
2012-2021
Shanghai Pulmonary Hospital
2012-2021
Peking Union Medical College Hospital
2013-2018
Abstract Interaction between programmed death-1 (PD-1) ligand 1 (PD-L1) on tumor cells and PD-1 T allows to evade cell-mediated immune surveillance. Strategies targeting PD-1/PD-L1 have shown clinical benefits in a variety of cancers. However, limited response rates hepatocellular carcinoma (HCC) prompted us investigate the molecular regulation PD-L1. Here, we identify B cell lymphoma-2-associated transcription factor (BCLAF1) as key PD-L1 regulator HCC. Specifically, BCLAF1 interacts with...
Next-generation sequencing of the exome and genome prostate cancers has identified numerous genetic alternations. SPOP (Speckle-type POZ Protein) was one most frequently mutated genes in primary cancer, suggesting is a potential driver cancer development progression. However, how mutations contribute to pathogenesis remains poorly understood. acts as an adaptor protein CUL3-RBX1 E3 ubiquitin ligase complex that generally recruits substrates for ubiquitination subsequent degradation....
Abstract Increasing amounts of evidence strongly suggests that dysregulation ubiquitin-proteasome system is closely associated with cancer pathogenesis. Speckle-type POZ protein (SPOP) an adapter the CUL3-based E3 ubiquitin ligase complexes. It selectively recruits substrates for their ubiquitination and subsequent degradation. Recently, several exome-sequencing studies endometrial revealed high frequency somatic mutations in SPOP (5.7–10%). However, how contribute to remains unknown. Here,...
Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently mutated gene in prostate cancer. The SPOP-mutated subtype of cancer shows high genomic instability, but underlying mechanisms causing this phenotype are still largely unknown. Here, we report that upon DNA damage, SPOP phosphorylated at Ser119 by ATM serine/threonine kinase, which potentiates binding to homeodomain-interacting kinase 2 (HIPK2), resulting a nondegradative ubiquitination HIPK2. This...
// Pingzhao Zhang 1,2,* , Yuanyuan 1,* Kun Gao 1 Yuqi Wang Xiaofeng Jin Youheng Wei Heige Saiyin Dejie 3 Jintao Peng 4 Jian Ma Yan Tang Reziya Wumaier Hongxiu Yu 2 Yimin Dong 5 Haojie Huang 6 Long and Chenji State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics Development, School Life Sciences, Fudan University, Shanghai, P.R. China Institutes Biomedical P. R. Department Gastroenterology, Jiangxi Institute Gastroenterology & Hepatology, The First...
Characterization of the exome and genome prostate cancers by next-generation sequencing has identified numerous genetic alternations. SPOP (speckle-type POZ protein) was as one most frequently affected genes somatic point mutations in cancer, suggesting is potentially a key driver for cancer development progression. However, how contribute to remains be elucidated. acts an adaptor protein CUL3-RBX1 E3 ubiquitin ligase complex selectively recruits substrates their ubiquitination subsequent...