A5015383151- Sarcoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Characterization and Applications of Magnetic Nanoparticles
- Immune cells in cancer
- interferon and immune responses
- RNA Interference and Gene Delivery
Shanghai Jiao Tong University
2019-2023
Shanghai Sixth People's Hospital
2020-2023
Fudan University Shanghai Cancer Center
2023
First Affiliated Hospital of Chinese PLA General Hospital
2012
Aim: To analyze the m6A methylome of osteosarcoma stem cells (OSCs). Materials & methods: Chemoresistant OSCs were enriched by doxorubicin treatment. Expression m6A-related enzymes was detected quantitative real-time-PCR and western blot. MeRIP-seq RNA-seq performed to identify differences in methylation gene expression. Data analysis conducted explore modified genes their clinical significance. Results: Three altered OSCs. Differentially methylated some pathways regulating pluripotency...
In recent years, cationic polymeric magnetic liposomes have shown greater stability and prolonged circulation half-life over traditional liposomes. Here, we examined the capability of in delivering drugs into brain under targeting with paclitaxel as loaded agent. We found that fabricated paclitaxel-loaded had a uniform diameter 20 nm were superparamagnetic. After they injected rats by caudal vein, concentration increased 2–5 folds without 5–15 after targeting. The high was maintained for...
Despite advances in neoadjuvant chemotherapy, outcomes for patients with osteosarcoma resistant to first-line chemotherapy have been dismal decades. There is thus an urgent need develop novel targeted drugs effectively treat refractory osteosarcoma. Dysregulation the PI3K/AKT pathway has observed during development of Herein, we first evaluated p-AKT (Ser473) expression levels tissue using high-throughput microarrays. Then, demonstrated role pictilisib, a potent PI3K inhibitor, and related...
Objective To find novel potential gene mutations other than EXT1 and EXT2 mutations, to expand the mutational spectrum of EXT explore correlation between clinical outcome genotype in patients with hereditary multiple exostoses (HME). Methods The study recruited seven families diagnosed osteochondromas (MO). Family histories information were collected detail through comprehensive physical image examination. Patients deformities functional limitations classified as “severe” remaining without...
Osteosarcoma, the most common primary malignant bone tumor, is currently treated with surgery combined chemotherapy, but limited availability of targeted drugs contributes to a poor prognosis. Identifying effective therapeutic targets crucial for improving prognosis osteosarcoma patients. We screened DepMap database identify essential genes as potential osteosarcoma. Gene Set Enrichment Analysis (GSEA) was employed elucidate biological roles these genes. Promising candidates were filtered...