A5020026659- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Aortic aneurysm repair treatments
- Central Venous Catheters and Hemodialysis
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Optical Coherence Tomography Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
- Helicobacter pylori-related gastroenterology studies
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
Saiseikai Yokohama Eastern Hospital
2016-2025
Kindai University
2017-2024
Saiseikai Ibaraki Hospital
2023
Kobe Pharmaceutical University
2019
Obayashi (Japan)
2013-2015
Dokkyo University
1991-2011
University of Shizuoka
2011
Maebashi Red Cross Hospital
2011
Dokkyo Medical University
2008-2010
The University of Tokyo
1967-2006
This article summarises recommendations for acute management of stroke by the European Stroke Initiative (EUSI), on behalf Council (ESC), Neurological Society (ENS), and Federation Societies (EFNS).
Angiotensin II (Ang II) receptor blocker (ARB) has been reported to have protective effects on the cardiovascular system independent of blood pressure reduction. Endothelial progenitor cells (EPCs) play a significant role in neovascularization ischemic tissue. The average lifespan EPCs was recently be shortened by oxidative stress and regulated anti-oxidative mechanisms. It that are present peripheral ability repair damage. We investigated an ARB, candesartan, EPC function oxidation...
Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigate whether telmisartan improves cardiovascular remodeling associated with production endothelial nitric oxide synthase (eNOS) through PPAR-gamma, inhibits Rho-kinase pathway, and suppresses oxidative stress in Dahl salt-sensitive (DS) hypertensive rats.Telmisartan (1 mg/kg per day)...
To compare feasibility and safety between ultrasound-guided conventional distal transradial access (dTRA).Distal access, a new technique for coronary angiography (CAG) percutaneous interventions (PCI), is safe feasible will become popular worldwide. Ultrasound-guided dTRA has been advocated to reduce failure rate access-site complications. However, date, the comparison of not reported.Overall, 137 patients (144 procedures) who underwent CAG or PCI using September 2018 February 2019 were...
Abstract An experimental and analytical study was conducted to determine the liquid natural frequencies resultant slosh forces in horizontal cylindrical tanks. This paper presents a of response small large wave heights. In former case, an effective calculation method longitudinal is presented by substituting equivalent rectangular tank for tank. The calculated frequencies, heights are good agreement with ones. transverse also discussed. latter impulsive were observed excitation, when hit top...
Although relaxin (RLX) has potent vasodilatory and anti-fibrotic properties, there is no information on its effects salt-sensitive hypertension. We investigated the of short-term treatment with RLX blood pressure (BP) nitric oxide synthase (NOS) protein in kidneys male Dahl (DS) salt-resistant (DR) rats after 1 week consumption an 8% NaCl diet. also evaluated inhibitory each specific NOS inhibitor BP during 1-week under high-salt Next, we examined long-term for 6 weeks renal histology...
Background: The differences in wound healing according to location remain unclear. Methods and Results: Between April 2007 October 2011, 138 patients (166 limbs) with critical limb ischemia tissue loss were treated endovascular treatment. On these limbs, 177 individual wounds identified on the foot evaluated for rates time their locations. Wound locations divided into 3 groups: group T (Toe wounds, n=112), H (Heel n=25), E (Extensive extending onto fore- or mid-foot along dorsum plantar...
Aims: We aimed to evaluate whether optical coherence tomography (OCT)-guided rotational atherectomy (RA) improves stent expansion and clinical outcomes compared intravascular ultrasound (IVUS)-guided RA. Methods results: From our database, we identified 247 de novo calcified coronary lesions that underwent RA between September 2013 December 2017. Of these, with no imaging data (n=11), poor image quality (n=7), balloon angioplasty alone (n=16), complications (two burr entrapments, two...
ABSTRACT Background and Aims When dealing with severely calcified lesions in endovascular therapy (EVT) for lower extremity artery disease (LEAD), navigating through chronic total occlusion (CTO) using hard‐tip guidewires can be challenging. To address this issue, we employed a novel highly intensive penetration (HIP) technique. This technique involves modifying the tail of 0.035‐inch guidewire to enhance its capability, thus enabling effective navigation lesion facilitating EVT procedure....
<title>Abstract</title> Purpose: This study aimed to reveal the impact of nodular calcification (NC) on restenosis risk in patients undergoing femoropopliteal drug-coated balloon (DCB) angioplasty for symptomatic atherosclerotic peripheral artery disease. Methods: We retrospectively analyzed 568 who underwent endovascular therapy with DCB de novo lesions under intravascular ultrasound guidance between November 2017 and February 2021 at seven cardiovascular centers Japan. Patients without...
We have demonstrated that angiotensin II receptor blocker (ARB) improved endothelial progenitor cells (EPCs) dysfunction through the antioxidative mechanism. Therefore, we investigate whether selective mineralocorticoid (MR) antagonist eplerenone improves EPCs function in rat hindlimb ischemia.Unilateral ischemia was surgically induced Wistar rats. After ischemia, rats received (30 mg/kg/day), valsartan (3 or vehicle for 3 weeks. Peripheral blood mononuclear were isolated, subjected to flow...
Objectives This study investigated the safety and prognosis of ultra‐long second DES (UL‐2nd DES) implantation in real‐world practice. Background Long stenting is a widely known predictor stent thrombosis (ST) or target lesion revascularization (TLR) first‐generation drug‐eluting stents (DES). Methods Participants were 1,669 patients (2,763 lesions) who had undergone successful implantation; they assigned to one three groups: 2nd (UL‐DES; >50 mm, 166 patients, 259 lesions), long (L‐DES;...
Abstract Objectives We clarified characteristics and clinical outcomes of critical limb ischemia (CLI) patients who underwent repeat endovascular therapy (EVT) for infrapopliteal lesions. Background High restenosis rate after EVT remains a major concern. Methods Patients with CLI between April 2007 February 2014, were divided into the following three groups according to how often was repeated: Group A, no EVT; B, repeated once/twice; C, ≥3 times. Results Wound healing rates at 1 year 93.9%...
Objectives The aim of this study was to assess clinical benefit the Echo‐guided ProGlide technique in patients undergoing percutaneous transfemoral transcatheter aortic valve implantation (TF‐TAVI). Background efficacy during TF‐TAVI not previously clarified. Methods A total 121 consecutive who underwent at our institution between February 2014 and July 2017 were enrolled study. According introduction novel March 2016, divided into two groups (echo‐guided group TAVI from 2016 2017, n = 63;...
We assessed wound healing in patients on hemodialysis (HD) with critical limb ischemia (CLI). This study enrolled 267 (including 120 HD and 147 not HD) who underwent endovascular therapy (EVT) for CLI. The primary endpoint was wound-healing rate at two years. Secondary endpoints were time to healing, recurrence rate, salvage percentage of male young higher the ( p < 0.01). A lower patency pedal arch after EVT observed frequently significantly (79.5% vs. 92.4%, 0.001). Time longer (median...
The hemodynamic effects of various numbers colored nonradioactive microspheres (CMS) and those accumulation CMS caused by multiple sequential injection were evaluated in 51 Sprague-Dawley male rats. (15 microns) injected into the left atrium. Regional blood flow cardiac output using reference sample technique. Ficoll-70 was given after each withdrawal as a fluid replacement. A bolus < or = 1,000,000 no significant disturbances. Amounts 500,000 can be repeatedly up to four times (cumulative...
In order to calculate the rocking response of unanchored cylindrical tank, including bottom uplift due seismic loading, a simple but effective method is developed. Firstly, an analysis model for presented; tank wall and liquid content are replaced with mass-spring system, nonlinearity associated partial plate considered as rotational spring bilinear type. The reliability this was illustrated by comparing calculation results resonance frequencies rotation angles models vibration tests....
Objectives To evaluate the predictors of non‐healing in patients with critical limb ischemia (CLI) after successful endovascular therapy (EVT). Background Occasionally, wound healing CLI and tissue loss cannot be achieved even EVT. Patient's co‐morbidities, vascular anatomy, features, interventional strategies/outcomes are associated probability healing. Methods Between April 2007 October 2012, 182 (220 limbs) were treated EVT our institute. Of these, 164 individual wounds (130 patients, 149...
To determine whether limb-based patency (LBP) after infrainguinal revascularization for chronic limb-threatening ischemia (CLTI) is similar between bypass surgery and endovascular therapy (EVT).The database the Surgical Reconstruction vs Peripheral Intervention in Patients With Critical Limb Ischemia (SPINACH) study was interrogated to identify 130 patients (mean age 73±8 years; 94 men) who underwent 271 74±10 178 EVT alone. Skin perfusion pressure (SPP) ankle-brachial index (ABI) were...