Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability.

The physical approach of a small particle (virus, medical drug) to the cell membrane represents crucial first step before active internalization and is governed by thermal diffusion. Using fully analytical theory we show that stretching bending elastic approaching induces memory in system which leads anomalous diffusion, even though immersed purely Newtonian liquid. For typical membranes transient subdiffusive regime extends beyond 10 ms can enhance residence times possibly binding rates up...

We combine confocal imaging, microfluidics and image analysis to record 3D-images of cells in flow. This enables us recover the full 3D representation several hundred living per minute. Whereas imaging has thus far been limited steady specimen, we overcome this restriction present a method access shape moving objects. The key our principle is tilted arrangement micro-channel with respect focal plane microscope. forces traverse an inclined manner. As consequence, individual layers passing are...

We study the motion of a solid particle immersed in Newtonian fluid and confined between two parallel elastic membranes possessing shear bending rigidity. The hydrodynamic mobility depends on frequency due to energy stored membrane. Unlike single-membrane case, coupling shearing exists. commonly used approximation superposing contributions is found give reasonable results only for motions direction, but not perpendicular direction. also compute analytically membrane deformation resulting...

The lateral migration of a vesicle (a model red blood cells) in bounded shear flow is investigated numerically. It found that there exists an off-center stable steady state the addition to usual centerline, depending on initial position and viscosity contrast.

A variety of numerical methods exist for the study deformable particles in dense suspensions. None standard tools, however, currently include volume-changing objects such as oscillating microbubbles three-dimensional periodic domains. In first part this work, we develop a novel method to entities based on boundary integral method. We show that well-known equation must be amended with two additional terms containing volume flux through bubble surface. rigorously prove existence and uniqueness...

Abstract Objective Knowledge about the flow field of plasma around red blood cells in capillary is important for a physical understanding and transport micro‐ nanoparticles molecules flowing plasma. We conducted an experimental study on that complemented by simulations vortical between cells. Methods Red were injected 10 × 12 µm rectangular microchannel at low hematocrit, one or two was captured high‐speed camera tracked 250 nm field, acting as tracers. Results While steady “croissant” shape...

A new class of pattern forming systems is identified and investigated: anisotropic that are spatially inhomogeneous along the direction perpendicular to preferred one. By studying generic amplitude equation this a model equation, we show branched stripe patterns emerge, which for given parameter set stable within band different wave numbers branching points (defects). Moreover, unbranched ones (defect-free stripes) coexist over finite range. We propose two where scenario can be found...

A variety of numerical methods exist for the study deformable particles in dense suspensions. None standard tools, however, currently include volume-changing objects such as oscillating microbubbles three-dimensional periodic domains. In first part this work, we develop a novel method to entities based on boundary integral method. We show that well-known equation must be amended with two additional terms containing volume flux through bubble surface. rigorously prove existence and uniqueness...

Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. Predicting the realized is complex field as they are determined by intricate interplay between flow conditions and membrane mechanics. In this work we construct shape phase diagram single red cell with physiological viscosity ratio in microchannel. We use both experimental in-vitro measurements well 3D numerical simulations complement respective other one. Numerically,...

Knowledge about the flow field of plasma around red blood cells in capillary is important for a physical understanding and transport micro- nanoparticles molecules flowing plasma. We conduct an experimental study on that are complemented by simulations vortical between cells. Red were injected 10x12 micrometer rectangular microchannel at low hematocrit single or two have been characterized thanks to highspeed camera tracking 250 nm behaving as tracers. While steady croissant shape found be...