A5100618279- Immune Response and Inflammation
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- S100 Proteins and Annexins
- TGF-β signaling in diseases
- Retinal Diseases and Treatments
- NF-κB Signaling Pathways
- Psoriasis: Treatment and Pathogenesis
- Sphingolipid Metabolism and Signaling
- Acute Kidney Injury Research
- Urinary and Genital Oncology Studies
- Inflammasome and immune disorders
- Male Breast Health Studies
- Lymphatic System and Diseases
- Vascular Malformations and Hemangiomas
- Cytokine Signaling Pathways and Interactions
- Central Venous Catheters and Hemodialysis
- Thyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- Medical Research and Treatments
- Adipose Tissue and Metabolism
- Multiple and Secondary Primary Cancers
- Glaucoma and retinal disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Infectious Encephalopathies and Encephalitis
Taiyuan Central Hospital
2020-2024
Shanxi Medical University
2017-2023
Huizhou Central People's Hospital
2018-2023
First Affiliated Hospital of Xi'an Jiaotong University
2014-2023
Second Hospital of Shanxi Medical University
2021-2023
Ningxia Medical University
2022
Shanghai Jiao Tong University
2022
ZheJiang Institute For Food and Drug Control
2022
Central Hospital of Wuhan
2021-2022
Huazhong University of Science and Technology
2021-2022
The cytotoxic effects of thirteen triterpene glycosides from Holothuria scabra Jaeger and Cucumaria frondosa Gunnerus (Holothuroidea) against four human cell lines were detected their cytotoxicity-structure relationships established. apoptosis-inducing activity a more potent glycoside echinoside A (1) in HepG2 cells was further investigated by determining its effect on the morphology, mitochondrial transmembrane potential (Δψm) mRNA expression levels apoptosis-related genes. results showed...
Acute lung injury (ALI) is a major cause of morbidity and mortality globally, characterized by widespread inflammation in the lungs. Increased production reactive oxygen species hypothesized to be associated with ALI. Matrine lycopene are active products present traditional Chinese medicine. an effective inhibitor inflammation, whereas decreases lipid peroxidation. Therefore, it was that combinatorial treatment matrine may provide synergistic protection against In study, mice were treated...
Abstract Psoriasis displays both increased angiogenesis and microvascular dilation in the skin, while human dermal endothelial cells (HDMECs) are involved dilation. Whether functions of HDMECs altered psoriatic skin versus healthy remain unknown. Here, we isolated from 10 patients with psoriasis subjects compared angiogenesis, proliferation, migration cell metabolism between normal HDMECs. We found that morphology primary was comparable After passage, displayed larger size wider...
The aim of this study was to establish plasma cytokine/chemokine profiles in patients with 3 different presentations active tuberculosis (TB), compared the observed bacillus Calmette-Guérin (BCG)-vaccinated healthy individuals and other pulmonary diseases (non-TB patients). To end, samples were collected from 151 TB including 68 (PTB), 43 endobronchial TB, 40 pleurisy (TP) patients, as well 107 no-TB cases 26 non-TB 81 BCG-vaccinated controls. A liquid array-based multiplexed immunoassay...
Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide.Glycosphingolipids (GSLs) are involved in infection by regulating various steps viral-host interaction.However, distinct role GSLs during DENV remains unclear.In this study, we used mouse melanoma B16 cells and their GSL-deficient mutant counterpart GM95 to study influence on infection.Surprisingly, were highly resistant compared with cells.Pretreatment synthetase inhibitor GM3, abundant cells, or...
Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumor-specific systemic immune act synergistically. To overcome limitations of combined use these two cytokines, we have constructed an IL2-GMCSF fusion protein characterized its effects in this study.The expression IL-2 receptor GM-CSF cell lines were detected with quantitative real-time...
Abstract Dermal microvascular endothelial cells (DMECs) play central roles in inflammation and angiogenesis have become important cell models for studying various skin diseases. However, primary DMECs are difficult to culture often contaminated by mesenchymal stem cells, fibroblasts, other stromal cells. Surgically removed superfluous foreskin was first cut into pieces, digested with two types of enzymes, dispersed single Cells obtained from the dermis were then subjected Percoll density...
Previous studies showed the link of CD14
Background: Cell proliferation, migration, and angiogenesis are aberrant in psoriatic human dermal microvascular endothelial cells (HDMECs), resulting abnormal function dilation psoriasis. Objective: To explore the role of Integrin subunit alpha 9 (ITGA9) proliferation migration cells. Methods: HDMECs were isolated from skin 6 patients healthy controls. Expression levels ITGA9 mRNA protein assessed with qRT-PCR Western blot, respectively, while miqRT-PCR was used to determine expression...
Aims To investigate the correlation between retinal microvasculature using optical coherence tomography angiography (OCTA) and systemic factors in type 2 diabetes mellitus (T2DM) patients. Methods This cross-sectional study obtained OCTA data from patients with T2DM administered at hospital referred to ophthalmic services. Patient about demographics, comorbid conditions, blood biomarkers were extracted electronic medical records. Data scans by CIRRUS HD-OCT Model 5,000 obtained. Vessel...
Abstract Objective Increased angiogenesis is a pathological feature of psoriasis, but the pathomechanisms in psoriasis are not clear. Interleukin‐17A (IL‐17A) major effect factor pathogenesis psoriasis. Our results showed that IL‐17A can promote and cause endothelial cell inflammation. Autophagy plays an important role only regulating inflammation, also angiogenesis. Whether related to autophagy remains unclear. In this study, we treated human umbilical vein cells (HUVECs) with simulate...
Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally administrated by intravenous infusion which liable to cause serious phlebitis. The therapeutic for preventing this complication are limited. Intermedin (IMD), a member calcitonin family, has broad spectrum biological effects including anti-inflammatory effects, antioxidant activities, antiapoptosis. But now, protective IMD against amiodarone-induced phlebitis underlying molecular mechanism not well understood. In...
The objective of the study was to investigate effects different intensity exercise and 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure on glucose metabolism in Sprague Dawley (SD) rats, as well action insulin receptor substrate (IRS)/phosphatidylinositol-3-kinases (PI3K)/protein kinase (AKT) signaling pathway it. Besides that, we explored whether can alleviate toxicity induced by TCDD. Sixty male SD rats (8 weeks old) were randomly divided into non-exercise group, none-exercise toxic...
The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate that improves antigen-specific both cellular and humoral immune responses elicits mixed Th1/Th2 responses, but its mechanisms remain unclear. key features action AJSAF were investigated in mice immunized with Newcastle disease virus-based recombinant influenza vaccine (rL-H5) at the same leg (AJSAF+rL-H5) or different legs (AJSAF/rL-H5). activity on rL-H5 strictly dependent their spatial...
This study aimed to explore the potential mechanisms of exercise prevent pelvic organ prolapse (POP) and search for diagnostic indictors POP.We used two clinical POP datasets with patients' information (GSE12852 GSE53868), a dataset consisting altered microRNA expression in circulating blood after (GSE69717) bioinformatic analysis analysis, while series cellular experiments were conducted preliminary mechanical validation.Our results show that AXUD1 is highly expressed smooth muscle ovary...
Bombyx batryticatus (BB) is an anticonvulsant animal medicine in traditional Chinese (TCM) and acts on the central nervous system. This research aimed to study effects of different polarity fractions extracts from BB explore components conferring activity. Materials methods: Crude at 20 g/kg were divided into (petroleum ether, chloroform, ethyl acetate, water) administered groups mice before injecting pentylenetetrazol (PTZ) induce convulsions. The animals placed chambers, their behaviors...
Abstract Objective Amiodarone (AM) is a drug commonly used in patients with ventricular arrhythmias. It can damage vascular endothelial cells and easily cause phlebitis. At present, the prevention treatment of phlebitis induced by use AM not clear due to lack corresponding primary research. Isoliquiritigenin (ISL) has an anti‐inflammatory effect, but until now, been explored much field research care nursing. The purpose this study investigate efficacy mechanism action ISL treating AM....
The aim of this study was to evaluate the clinical efficacy an intravitreal injection ranibizumab combined with argon ion laser photocoagulation therapy in treatment different degrees central retinal vein occlusion (CRVO). A total 112 CRVO patients including 25 cases trunk occlusion, 50 branch and 37 hemiretinal vein-occlusion were enrolled study. Patients treated 0.5 mg ranibizumab, followed by after 7 days. up for 6 months best corrected visual acuity (BCVA), thickness (CRT), macular...