A5028965157- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Facial Trauma and Fracture Management
- Olfactory and Sensory Function Studies
- Sharing Economy and Platforms
- Advanced Chemical Sensor Technologies
- Axon Guidance and Neuronal Signaling
- Nasal Surgery and Airway Studies
- Traumatic Ocular and Foreign Body Injuries
- Oral and Maxillofacial Pathology
- Phagocytosis and Immune Regulation
- Vascular Malformations and Hemangiomas
- Meningioma and schwannoma management
- Virus-based gene therapy research
- Dental Radiography and Imaging
- Extraction and Separation Processes
- Gastric Cancer Management and Outcomes
- Ear Surgery and Otitis Media
- Nerve injury and regeneration
- Patient-Provider Communication in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
Osaka Hospital
2022-2025
Osaka University
2016-2025
Japan Community Healthcare Organization
2023-2025
Okayama University
2019-2024
Sakai Municipal Hospital
2023
Tokyo Metropolitan Geriatric Hospital
2023
Ritsumeikan University
2023
Tokyo Electron (Japan)
2023
Yao Tokushukai General Hospital
2018-2021
Osaka International University
2015-2018
Abstract Macrophages play crucial roles in host defence and tissue homoeostasis, processes which both environmental stimuli intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 M2 It remains unclear how intracellular nutrition sufficiency, especially for amino acid, influences on macrophage activation. Here we show that a lysosomal adaptor protein Lamtor1, forms an amino-acid sensing complex with vacuolar-type H + -ATPase...
Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of (CRS) that characterized by intractable nasal polyp formation. Eosinophil-derived neurotoxin (EDN) an eosinophil granule protein closely related to allergic inflammation, but the pathological implications EDN in ECRS remain unknown. In this study, we evaluated function pathogenesis and assessed its potential as disease activity marker. Serum levels were significantly higher patients with than those other paranasal diseases,...
Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with COPD-like phenotype progressively developed syndrome resembling human including cataracts, hair loss, atrophy various organs, thymus, muscle, testis, resulting shorter survival than wild-type (WT) mice....
Mammalian target of rapamycin (mTOR) plays crucial roles in activation and differentiation diverse types immune cells. Although several lines evidence have demonstrated the importance mTOR-mediated signals CD4(+) T cell responses, involvement mTOR CD8(+) responses is not fully understood. In this study, we show that a class IV semaphorin, SEMA4A, regulates through complex (mTORC) 1. SEMA4A(-/-) cells exhibited impairments production IFN-γ TNF-α induction effector molecules granzyme B,...
Chronic rhinosinusitis (CRS) is an inflammatory disease of the upper respiratory tract. Although previously classified based on presence or absence nasal polyps, it now commonly by endotype. Eosinophilic CRS (ECRS) type 2 inflammation and formation intractable polyps with eosinophil infiltration. Endoscopic surgery preferred treatment modality; however, recurrent cases are common. The central compartment cavity has been implicated in these recurrences. Notably, middle turbinate considered...
Semaphorin 4A (Sema4A) has an essential role in photoreceptor survival. In humans, mutations Sema4A are thought to contribute retinal degenerative diseases. Here we generate a series of knock-in mouse lines with corresponding (D345H, F350C or R713Q) the gene and find that Sema4AF350C causes degeneration phenotypes. The mutation results abnormal localization protein, leading impaired endosomal sorting molecules indispensable for Additionally, protein structural modelling reveals side chain...
B-cell receptor (BCR) signaling plays a critical role in activation and humoral immunity. In this study, we discovered function of leucine-rich repeat kinase 1 (LRRK1) BCR-mediated immune responses. Lrrk1(-/-) mice exhibited altered B1a-cell development basal immunoglobulin production. addition, these failed to produce IgG3 antibody response T cell-independent type 2 antigen due defects class-switch recombination. Concomitantly, B cells lacking LRRK1 profound defect proliferation survival...
Abstract Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid–activated mechanistic target of rapamycin complex 1 (mTORC1), is critical polarization M2 However, little known about how Lamtor1 affects inflammatory responses are triggered by stimuli TLRs. In this article, show controls regulating phosphorylation and nuclear translocation...
Chronic rhinosinusitis is classified into eosinophilic chronic (ECRS) and non-eosinophilic (NECRS). ECRS a refractory allergic disease involving variety of immune epithelial cells. S100A8 damage-associated molecular pattern that closely related to inflammation. However, the pathological implications in have not been clarified.We evaluated role pathogenesis ECRS. Gene expression profiles nasal polyps obtained from patients with or NECRS were using RNA sequencing.S100A8 was identified as...
In this study, we present a new concept in chemically stabilized ionic liquid membranes: an organosilica (ILOS) membrane, which is membrane with liquid-like properties. A silylated was used as precursor for synthesis. The permselectivity, permeation mechanism, and stability of the H2/toluene binary system were then compared supported membrane. showed superior separation factor toluene/H2 (>17,000) mixture based on solution–diffusion mechanism improved durability over
In this paper, a new method is proposed to determine the optimal allocation of FACTS (flexible AC transmission system) devices. The makes use two-layered tabu search that evaluates integer and continuous variables. emergence power market system operators consider how maximize capability. UPFC employed control flows so capability maximized. This paper determines for several load patterns with search. effective demonstrated in sample