MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 233:273-281 (2002) - doi:10.3354/meps233273 Size-related differences in feeding habitat use of adult female loggerhead turtles Caretta caretta around Japan determined by stable isotope analyses and satellite telemetry Hideo Hatase1,*, Noriyuki Takai1,**, Yoshimasa Matsuzawa1,***, Wataru Sakamoto1, Kazuyoshi...

Abstract Purpose: HDAC inhibitors (HDACIs) have been shown to inhibit cancer cell proliferation, stimulate apoptosis, and induce cycle arrest. Our purpose was investigate the antiproliferative effects of HDACIs [suberoyl anilide bishydroxamine, valproic acid (VPA), trichostatin A, sodium butyrate] against six endometrial lines. Experimental Design: Endometrial cells were treated with a variety HDACIs, effect on growth, cycle, apoptosis measured. The ability VPA growth tumors growing in...

Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression deacetylation the promoter regions, mediated histone deacetylase (HDAC). HDAC inhibitors block cancer cell growth restoring expression of tumor genes. In study, we investigated effects a inhibitor, suberoylanilide hydroxamic acid (SAHA) on pancreatic cells. SAHA inhibited 6 lines dose‐dependent manner as measured MTT and clonogenic assays (ED 50 ≈10 −6 M) associated with induction...

Bufalin is a traditional Chinese medicine and it induces apoptosis in certain human tumor cell lines. We investigated the effect of bufalin on three endometrial cancer lines, two ovarian normal epithelial cells. Endometrial cells were treated with various concentrations bufalin, its growth, cycle, apoptosis, related measurements was investigated. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that all lines sensitive to growth-inhibitory although viable after...

Abstract BACKGROUND Histone deacetylase inhibitors (HDACIs) can inhibit proliferation, stimulate apoptosis, and induce cell cycle arrest in malignant cells. METHODS The authors investigated the effects of four HDACIs on nine ovarian carcinoma lines vitro vivo. Ovarian cells were treated with a variety HDACIs, their growth, cycle, related events investigated. ability valproic acid (VPA) to growth tumors immunodeficient mice was also assessed. RESULTS Clonogenic assays showed that all...

The magnitude of geographical variations stable isotope ratios carbon and nitrogen was examined in ten squid species captured seven areas the world's oceans. average all 139 −17.4±1.4‰ for δ 13 C 11.6±1.6‰ 15 N. showed a clear-cut negative correlation with latitude sampling locations, reflecting well-known latitudinal characteristics phytoplankton C, while δ, N did not correlate significantly. reflected regional metabolism such as denitrification 2 fixation, it conspicuous intraspecific...

In order to evaluate the involvement of cell proliferation and apoptosis in pathogenesis endometriosis, we investigated effects interferon-gamma (IFN-gamma) on growth inhibition cultured ovarian endometriotic cyst stromal cells (ECSC), eutopic endometrial with endometriosis (ESCwE) normal (NESC) by modified methylthiazoletetrazolium assay, 5-bromo-2'-deoxyuridine incorporation assay internucleosomal DNA fragmentation assay. The expression apoptosis-related molecules IFN-gamma receptor 1 was...

BACKGROUNDAccumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. We investigated histone acetylation status endometriosis and application deacetylase inhibitors (HDACIs) for treatment

Bufalin is a traditional oriental medicines which induces apoptosis in some lines of human tumor cells. It constitutes the major digoxin-like immunoreactive component Chan Su, obtained from skin and parotid venom glands toads. cardioactive C-24 steroids that exhibits variety biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory antineoplastic effects. In terms its anti-tumor activity, bufalin has been demonstrated to inhibit growth tumors,...

The relative importance of benthic and pelagic primary production for demersal fish some invertebrates in the western Seto Inland Sea Japan was examined using carbon nitrogen stable isotope analyses. A few fishes, such as juvenile black rockfish Sebastes inermis large Japanese anchovies Engraulis japonicus , had isotopic signatures similar to particulate organic matter (−20.1 ³ 1.7‰), which indicates that their food derived from water column. However, 92% 401 were analyzed δ 13 C (−17.0...

Most of the current medical treatments for endometriosis aim to down-regulate estrogen activity. However, a high recurrence rate after has been most significant problem. Bufalin is major digoxin-like immunoreactive component isolated from skin and parotid venom glands toad considered an apoptosis-inducing agent. To apply bufalin treatment endometriosis, we investigated effects this agent on cell proliferation apoptosis cultured ovarian endometriotic cyst stromal cells (ECSC) by modified...

Abstract Realization that many tumor suppressor genes are silenced by epigenetic mechanisms has stimulated the discovery of novel genes. We used a variety research tools to search for epigenetically in human endometrial cancers. Changes global gene expression cancer cell line Ishikawa was analyzed after treatment with demethylating agent 5-aza-2′-deoxycytidine combined histone deacetylase inhibitor suberoylanilide bishydroxamide. By screening over 22,000 genes, candidate were identified....

Small cell carcinoma of the uterine cervix is a rare form cervical cancer characterized by extreme aggressiveness and poor prognosis because its rapid growth, frequent distant metastases, resistance to conventional treatment modalities. We report here case advanced-stage small treated neoadjuvant chemotherapy, followed radical surgery, resulting in locoregional disease control. A 39-year-old Japanese woman was diagnosed as having stage IIIb cervix. She chemotherapy with irinotecan/cisplatin,...

Abstract BACKGROUND Human epidermal growth factor receptor 2 (HER2) is overexpressed in 25–30% of ovarian carcinoma cases and a correlation between increased HER2 expression decreased survival has been demonstrated. ligand‐less member the HER family that functions as preferred coreceptor for (EGFR), HER3, HER4. METHODS An approach was developed to target HER2's role using monoclonal antibody, 2C4, which sterically hinders recruitment into functional complex. RESULTS robustly expressed all...

Histone deacetylase inhibitors (HDACIs) can inhibit proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells. Our purpose was to investigate the antiproliferative effects a novel HDACI, apicidin, on Ishikawa endometrial line, SK-OV-3 ovarian line normal human epithelial Endometrial cells were treated with various concentrations growth, cycle, related measurements investigated. MTT assays showed that all lines sensitive growth inhibitory effect although viable after...