A5073112406- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Thermal Regulation in Medicine
- Hormonal and reproductive studies
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Prostate Cancer Diagnosis and Treatment
- Reproductive System and Pregnancy
- TGF-β signaling in diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Climate Change and Health Impacts
- NF-κB Signaling Pathways
- Immune cells in cancer
- Burn Injury Management and Outcomes
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Cardiovascular and Diving-Related Complications
University of Nebraska Medical Center
2011-2023
New York University
2017-2023
National Cancer Institute
2013
Center for Cancer Research
2013
AdventHealth Tampa
2010
Moffitt Cancer Center
2010
Reata Pharmaceuticals (United States)
2010
Texas Oncology
2010
Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means modulate these cells.We evaluated effect synthetic triterpenoid C-28 methyl ester 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid (CDDO-Me; bardoxolone methyl) MC38 colon carcinoma, Lewis lung and EL-4 thymoma mouse tumor models, as well blood samples from patients with renal cell cancer soft tissue sarcoma....
Abstract The nature of the regulatory cell types that dominate in any given tumor is not understood at present. Here, we addressed this question for T cells (Treg) and type II natural killer (NKT) syngeneic models colorectal renal cancer. In mice with both I NKT cells, or neither cell, Treg depletion was sufficient to protect against outgrowth. Surprisingly, lacking only blockade insufficient protection. Thus, hypothesized may be neutralized by leaving Tregs as primary suppressor, whereas...
Background Understanding drivers for metastasis in human cancer is important potential development of therapies to treat metastases. The role loss TGFβ tumor suppressor activities the metastatic process essentially unknown. Methodology/Principal Findings Utilizing vitro and vivo techniques, we have shown that signaling necessary allow last step - colonization site. This work demonstrates first time receptor reconstitution leads decreased colonization. Moreover, identified a novel TGFβ/PKA...
Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment, given the dependence cells on androgen and receptor (AR). However, tumors become ADT-resistant, there need to understand mechanism. One possible mechanism upregulation AR co-regulators, although only handful have been definitively linked disease. We previously identified Mediator subunit MED19 as an co-regulator, reported that depletion inhibits transcriptional activity growth androgen-insensitive LNCaP-abl cells....
Abstract Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory is one major causes death critically ill patients with a reported mortality rate up 45%. The present study focuses on effect oxygen microbubble (OMB) infusion via colon porcine model smoke inhalation-induced lung injury. Juvenile female Duroc pigs ( n = 6 colonic OMB, no treatment) ranging from 39 51 kg weight were exposed under general...
Acute respiratory distress syndrome (ARDS) is multifactorial and can result from sepsis, trauma, or pneumonia, amongst other primary pathologies. It one of the major causes death in critically ill patients with a reported mortality rate up to 45%. The present study focuses on development large animal model smoke inhalation-induced ARDS an effort provide scientific community reliable, reproducible isolated toxic inhalation injury-induced ARDS.Animals (n = 21) were exposed under general...
Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a lethal disease with limited therapeutic options and an unacceptably high mortality rate. Understanding the complex pathophysiological processes involved in development of ALI/ARDS critical for developing novel strategies. Smoke inhalation (SI) leading cause morbidity patients burn-associated ALI/ARDS; however, to our knowledge few reliable, reproducible models are available pure SI animal model investigate...
Abstract MED19, a component of the mediator complex and co-regulator androgen receptor (AR), is pivotal in prostate cancer cell proliferation. MED19 has two isoforms: full-length “canonical” shorter “alternative” variant. Specific antibodies were developed to investigate these isoforms. Both exhibit similar expression normal development adult tissue, but canonical isoform elevated adenocarcinomas. Overexpression LNCaP cells promotes growth under conditions deprivation vitro vivo, mirroring...
Patients suffering from severe acute respiratory distress syndrome (ARDS) face limited therapeutic options and alarmingly high mortality rates. Refractory hypoxemia, a hallmark of ARDS, often necessitates invasive high-risk treatments. Oxygen microbubbles (OMB) present promising approach for extrapulmonary oxygenation, potentially augmenting systemic oxygen levels without exposing patients to significant risks.Rats with severe, hypoxemia secondary wood smoke inhalation (SI) received...
Abstract Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory is one major causes death critically ill patients with a reported mortality rate up 45%. The present study focuses on effect oxygen microbubble (OMB) infusion via colon porcine model smoke inhalation-induced lung injury. Juvenile female Duroc pigs (n=6 colonic OMB, n=6 no treatment) ranging from 39-51 kg weight were exposed under general...
Abstract Androgen deprivation therapy (ADT) is a mainstay of prostate cancer treatment, given the dependence cells on androgen and receptor (AR). However, tumors become ADT-resistant, there need to understand mechanism. One possible mechanism upregulation AR co-regulators, although only handful have been definitively linked disease. We previously identified Mediator subunit MED19 as an co-regulator, reported that depletion inhibits transcriptional activity growth androgen-insensitive...
Abstract Background Acute respiratory distress syndrome (ARDS) is multifactorial and can result from sepsis, trauma, or pneumonia, amongst other primary pathologies. It one of the major causes death in critically ill patients with a reported mortality rate up to 45%. The present study focuses on development large animal model smoke inhalation-induced ARDS an effort provide scientific community reliable, reproducible isolated toxic inhalation injury-induced ARDS. Methods Animals (n = 21) were...