A5116609407- Immune Cell Function and Interaction
- Mass Spectrometry Techniques and Applications
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
Ghent University
2025
Cancer Research Institute Ghent
2025
The COVID-19 pandemic has catalyzed interest in immuno-multiple reaction monitoring (immuno-MRM) methods, with the detection of peptides unique to nucleocapsid protein nasopharyngeal swabs. While current applications predominantly focus on disease biomarkers, unveiled new opportunities, namely for quantification antigen expression following mRNA vaccination. Here, we present an optimized immuno-MRM method quantifying SARS-CoV-2 spike fusion peptide, SFIEDLLFNK, several practical...
Background Invariant natural killer T (iNKT) cells and CD8 + are key in the immune response against multiple myeloma (MM), a largely incurable blood cancer. Immunization is promising strategy to activate these cell populations. To our knowledge, immunization with messenger RNA (mRNA) iNKT agonist, α-galactosylceramide (αGC), has not been studied MM, as knowledge on clinically relevant antigens preclinical MM models lacking. Methods Microarray data immunopeptidomics (imPep) were used identify...